Towards the development of a bioartificial pancreas: long-term in vitro functions of immunoisolated mouse insulinoma cells

Thanassis Sambanis, Klearchos K. Papas, Robert C. Long, Ioannis Constantinidis

Research output: Contribution to conferencePaper

Abstract

The development of stable, functional bioartificial constructs based on transformed insulin-secreting cells that can be amplified in culture thus relaxing the cell availability constrain has been investigated. The system used consists of mouse insulinoma βTC3 cells entrapped in calcium APA beads. A perfusion bioreactor and radiofrequency coil were developed for maintaining entrapped cells in the long-term and for carrying out non-invasive NMR studies of cellular biochemistry.

Original languageEnglish (US)
Pages259-260
Number of pages2
StatePublished - Dec 1 1996
Externally publishedYes
EventProceedings of the 1996 ASME International Mechanical Engineering Congress and Exposition - Atlanta, GA, USA
Duration: Nov 17 1996Nov 22 1996

Other

OtherProceedings of the 1996 ASME International Mechanical Engineering Congress and Exposition
CityAtlanta, GA, USA
Period11/17/9611/22/96

ASJC Scopus subject areas

  • Engineering(all)

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    Sambanis, T., Papas, K. K., Long, R. C., & Constantinidis, I. (1996). Towards the development of a bioartificial pancreas: long-term in vitro functions of immunoisolated mouse insulinoma cells. 259-260. Paper presented at Proceedings of the 1996 ASME International Mechanical Engineering Congress and Exposition, Atlanta, GA, USA, .