Towards the recapitulation of ancient history in the laboratory: Combining synthetic biology with experimental evolution

Betül Kaçar, Eric Gaucher

Research output: Chapter in Book/Report/Conference proceedingConference contribution

11 Scopus citations

Abstract

One way to understand the role history plays on evolutionary trajectories is by giving ancient life a second opportunity to evolve. Our ability to empirically perform such an experiment, however, is limited by current experimental designs. Combining ancestral sequence reconstruction with synthetic biology allows us to resurrect the past within a modern context and has expanded our understanding of protein functionality within a historical context. Experimental evolution, on the other hand, provides us with the ability to study evolution in action, under controlled conditions in the laboratory. Here we describe a novel experimental setup that integrates two disparate fields - ancestral sequence reconstruction and experimental evolution. This allows us to rewind and replay the evolutionary history of ancient biomolecules in the laboratory. We anticipate that our combination will provide a deeper understanding of the underlying roles that contingency and determinism play in shaping evolutionary processes.

Original languageEnglish (US)
Title of host publicationArtificial Life 13
Subtitle of host publicationProceedings of the 13th International Conference on the Simulation and Synthesis of Living Systems, ALIFE 2012
Pages11-18
Number of pages8
StatePublished - Dec 1 2012
Externally publishedYes
Event13th International Conference on the Simulation and Synthesis of Living Systems: Artificial Life 13, ALIFE 2012 - East Lansing, MI, United States
Duration: Jul 19 2012Jul 22 2012

Publication series

NameArtificial Life 13: Proceedings of the 13th International Conference on the Simulation and Synthesis of Living Systems, ALIFE 2012

Conference

Conference13th International Conference on the Simulation and Synthesis of Living Systems: Artificial Life 13, ALIFE 2012
CountryUnited States
CityEast Lansing, MI
Period7/19/127/22/12

ASJC Scopus subject areas

  • Modeling and Simulation

Fingerprint Dive into the research topics of 'Towards the recapitulation of ancient history in the laboratory: Combining synthetic biology with experimental evolution'. Together they form a unique fingerprint.

  • Cite this

    Kaçar, B., & Gaucher, E. (2012). Towards the recapitulation of ancient history in the laboratory: Combining synthetic biology with experimental evolution. In Artificial Life 13: Proceedings of the 13th International Conference on the Simulation and Synthesis of Living Systems, ALIFE 2012 (pp. 11-18). (Artificial Life 13: Proceedings of the 13th International Conference on the Simulation and Synthesis of Living Systems, ALIFE 2012).