Toxic shock-like syndrome

Brian L Erstad, C. L. Witte, D. F. Talkington

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Invasive group A streptococcal infection has important diagnostic and therapeutic implications in patients with necrotizing fasciitis. We cared for a man with the full-blown syndrome in whom many features of toxic shock syndrome were present, including profound hypotension and renal failure. The diagnostic similarities of toxic shock syndrome and the toxic shock-like syndrome caused by group A Streptococcus could have led to inappropriate treatment. Successful therapy in our patient included high doses initially of broad-spectrum antibiotics, repeated operative debridement of the lower leg (the affected limb), and ultimately, reconstructive surgery consisting primarily of split-thickness skin grafts. The reemergence of invasive streptococcal infections may relate to changes either in virulence factors of the causative streptococcus or in exotoxins elaborated by this microorganism. A causative relationship between an exotoxin produced by group A Streptococcus and the toxic shock-like syndrome has not yet been established.

Original languageEnglish (US)
Pages (from-to)23-27
Number of pages5
JournalPharmacotherapy
Volume12
Issue number1
StatePublished - 1992

Fingerprint

Septic Shock
Streptococcus
Exotoxins
Streptococcal Infections
Reconstructive Surgical Procedures
Necrotizing Fasciitis
Virulence Factors
Debridement
Hypotension
Renal Insufficiency
Leg
Therapeutics
Extremities
Anti-Bacterial Agents
Transplants
Skin

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Erstad, B. L., Witte, C. L., & Talkington, D. F. (1992). Toxic shock-like syndrome. Pharmacotherapy, 12(1), 23-27.

Toxic shock-like syndrome. / Erstad, Brian L; Witte, C. L.; Talkington, D. F.

In: Pharmacotherapy, Vol. 12, No. 1, 1992, p. 23-27.

Research output: Contribution to journalArticle

Erstad, BL, Witte, CL & Talkington, DF 1992, 'Toxic shock-like syndrome', Pharmacotherapy, vol. 12, no. 1, pp. 23-27.
Erstad BL, Witte CL, Talkington DF. Toxic shock-like syndrome. Pharmacotherapy. 1992;12(1):23-27.
Erstad, Brian L ; Witte, C. L. ; Talkington, D. F. / Toxic shock-like syndrome. In: Pharmacotherapy. 1992 ; Vol. 12, No. 1. pp. 23-27.
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