Toxicity and biotransformation of volatile halogenated anesthetics in rat hepatocyte suspensions

A. B. Direnzo, A Jay Gandolfi, S. D. Brooks, K. Brendel

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

This study, examines the toxicity (as measured by reduced intracellular K+ and metabolism (defluorination) of halothane and enflurane in rat hepatocytes in suspension (RHS) with regards to O2 tension, time, and concentration. In 95% O2 halothane is more toxic than enflurane when RHS are exposed to 5-20 μ1 of these anesthetics. At these levels halothane is not metabolized while enflurane is metabolized. At 21% O2 a similar pattern was seen with regards to toxicity. However, metabolism of halothane rapidly reached an elevated level while that of enflurane is reduced when compared to 95% O2. Thus toxicity of halothane and enflurane at these dose levels appears to be unrelated to metabolism and due solely to a solvent effect.

Original languageEnglish (US)
Pages (from-to)207-218
Number of pages12
JournalDrug and Chemical Toxicology
Volume8
Issue number4
DOIs
StatePublished - 1985

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Enflurane
Anesthetics
Halothane
Biotransformation
Metabolism
Toxicity
Rats
Hepatocytes
Suspensions
Poisons

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Health, Toxicology and Mutagenesis
  • Public Health, Environmental and Occupational Health
  • Chemical Health and Safety
  • Chemistry(all)

Cite this

Toxicity and biotransformation of volatile halogenated anesthetics in rat hepatocyte suspensions. / Direnzo, A. B.; Gandolfi, A Jay; Brooks, S. D.; Brendel, K.

In: Drug and Chemical Toxicology, Vol. 8, No. 4, 1985, p. 207-218.

Research output: Contribution to journalArticle

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