Toxicology of quinone-thioethers

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Abstract

Cytotoxicity associated with exposure to quinones has generally been attributed to either redox cycling, and the subsequent development of "oxidative stress" and/or to their interaction with cellular nucleophiles, such as protein and non-protein sulfhydryls. Glutathione (GSH) is the major non-protein sulfhydryl present in cells, and conjugation of potentially toxic electrophiles with GSH is usually associated with detoxication and excretion. However, this review discusses the biological (re)activity of quinone-thioethers. For example, quinone-thioethers are (1) capable of redox cycling (2) substrates for, and inhibitors of, a variety of enzymes (3) methemoglobinemic (4) potent nephrotoxicants (5) DNA reactive and (6) may contribute to quinone-mediated carcinogenicity and neurotoxicity. The ubiquitous nature of quinones, and the high intracellular concentrations of GSH, ensures that cells and tissues will be exposed to quinone-thioethers. The toxicological importance of quinone-thioethers in quinone-mediated toxicities therefore deserves further attention.

Original languageEnglish (US)
Pages (from-to)243-270
Number of pages28
JournalCritical Reviews in Toxicology
Volume22
Issue number5-6
DOIs
StatePublished - Jan 1 1992

Keywords

  • Glutathione
  • Glutathione conjugates
  • Nephrocar-cinogenicity
  • Nephrotoxicity
  • Neurotoxicity
  • Quinines
  • Quinone-thioethers

ASJC Scopus subject areas

  • Toxicology

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