Traffic jams

Protein transport in Plasmodium falciparum

G. G. Van Dooren, R. F. Waller, G. I. McFadden, Keith A Joiner, D. S. Roos

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Protein targeting in malaria parasites is a complex process, involving several cellular compartments that distinguish these cells from more familiar systems, such as yeast or mammals. At least a dozen distinct protein destinations are known. The best studied of these is the vestigial chloroplast (the apicoplast), but new tools promise rapid progress in understanding how Plasmodium falciparum and related apicomplexan parasites traffic proteins to their invasion-related organelles, and how they modify the host by trafficking proteins into its cytoplasm and plasma membrane. Here, Giel van Dooren and colleagues discuss recent insights into protein targeting via the secretory pathway in this fascinating and important system. This topic emerged as a major theme at the Molecular Approaches to Malaria conference, Lorne, Australia, 2-5 February 2000. Copyright (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)421-427
Number of pages7
JournalParasitology Today
Volume16
Issue number10
DOIs
StatePublished - Oct 1 2000
Externally publishedYes

Fingerprint

Protein Transport
Plasmodium falciparum
Malaria
Parasites
Apicoplasts
Secretory Pathway
Chloroplasts
Organelles
Mammals
Cytoplasm
Proteins
Yeasts
Cell Membrane

ASJC Scopus subject areas

  • Parasitology

Cite this

Van Dooren, G. G., Waller, R. F., McFadden, G. I., Joiner, K. A., & Roos, D. S. (2000). Traffic jams: Protein transport in Plasmodium falciparum. Parasitology Today, 16(10), 421-427. https://doi.org/10.1016/S0169-4758(00)01792-0

Traffic jams : Protein transport in Plasmodium falciparum. / Van Dooren, G. G.; Waller, R. F.; McFadden, G. I.; Joiner, Keith A; Roos, D. S.

In: Parasitology Today, Vol. 16, No. 10, 01.10.2000, p. 421-427.

Research output: Contribution to journalArticle

Van Dooren, GG, Waller, RF, McFadden, GI, Joiner, KA & Roos, DS 2000, 'Traffic jams: Protein transport in Plasmodium falciparum', Parasitology Today, vol. 16, no. 10, pp. 421-427. https://doi.org/10.1016/S0169-4758(00)01792-0
Van Dooren, G. G. ; Waller, R. F. ; McFadden, G. I. ; Joiner, Keith A ; Roos, D. S. / Traffic jams : Protein transport in Plasmodium falciparum. In: Parasitology Today. 2000 ; Vol. 16, No. 10. pp. 421-427.
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