Transcapillary water and protein flux in the canine intestine with acute and chronic extrahepatic portal hypertension

C. L. Witte, J. F. Myers, Marlys H Witte, M. A. Katz

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Abstract

Intestinal transcapillary water and total protein flux were determined in dogs with chronic extrahepatic portal hypertension after construction of an aortic-portal shunt combined with hilar portal vein constriction and compared to acute portal vein constriction. Measurements were made of thoracic duct lymph flow, portal venous pressure, and total protein concentration in plasma, thoracic duct lymph, intestinal and liver lymph. From these data and calculations based on the dual visceral origin of thoracic duct lymph from liver and intestine, intestinal transcapillary water flux in chronic extrahepatic portal hypertension (portal venous pressure = 21.4 ± 2 mm Hg; mean ± SEM), increased 5-fold (93 ± 12 from 17 ± 4 μl/min/kg, P < 0.001), while intestinal total protein flux expressed as protein clearance (intestinal transcapillary water flux x intestinal lymph/plasma total protein concentration) was unchanged (13 ± 3 from 10 ± 2 μl/min per kg; P > 0.4), a finding supported by unaltered whole body plasma albumin 'leak rate' (83 ± 16 from 80 ± 2 μl/min per kg; P > 0.9). In acute portal vein constriction (portal venous pressure = 26 ± 1 mm Hg) intestinal transcapillary water flux was similarly increased (58 ± 16 from 9 ± 2; P < 0.014) but intestinal total protein flux was increased 3-fold (16 ± 4 from 5 ± 2; P < 0.032). Calculated permeability surface area product and protein reflection coefficient (cross-point method) increased similarly in both preparations. In accord with earlier findings in patients with hepatic cirrhosis, chronic elevation in portal pressure increased intestinal transcapillary water flux but not total protein flux.

Original languageEnglish (US)
Pages (from-to)622-629
Number of pages8
JournalCirculation Research
Volume53
Issue number5
StatePublished - 1983

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Portal Hypertension
Portal Pressure
Intestines
Canidae
Lymph
Thoracic Duct
Portal Vein
Constriction
Water
Proteins
Liver
Serum Albumin
Liver Cirrhosis
Permeability
Dogs

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Transcapillary water and protein flux in the canine intestine with acute and chronic extrahepatic portal hypertension. / Witte, C. L.; Myers, J. F.; Witte, Marlys H; Katz, M. A.

In: Circulation Research, Vol. 53, No. 5, 1983, p. 622-629.

Research output: Contribution to journalArticle

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