Transfer of peanut allergy from donor to recipient after liver transplant

Avin Aggarwal, Rilwan Balogun, Tara F. Carr, Archita Desai, Tun Jie, Jen Jung Pan

Research output: Contribution to journalArticle

Abstract

31 years old female with a history of contact dermatitis, eczema, allergic rhinitis, pernicious anemia, alopecia areata and latent tuberculosis was treated concurrently with methotrexate along with isoniazid and pyridoxine. Five months into the therapy she developed acute onset jaundice progressing into fulminant liver failure with altered mentation and worsening liver function tests. Extensive workup including serological and histopathological evaluation revealed drug-induced liver injury as the etiology of her liver failure and she underwent a successful orthotropic liver transplant. On post-transplant follow-up at four months, she was noted to have an allergic reaction consisting of a perioral rash and swelling (without anaphylaxis) after receiving a kiss from her significant other who had just eaten a peanut butter chocolate. She denied any history of allergic reaction to peanuts prior to the transplant. Percutaneous skin testing revealed immediate hypersensitivity to peanut, hazelnut, and pecan believed to be acquired newly post-transplant. Further investigation revealed that the organ donor had a documented history of systemic anaphylaxis from the peanut allergy and a positive peanut-specific IgE level. Also, another parallel solid organ recipient (lung transplant) from the same organ donor experienced a serious anaphylactic reaction after peanut exposure. This is a case of food (peanut) allergy transfer from the donor to the recipient after the liver transplant. This case highlights the importance of incorporating known donor allergies as a part of pre-transplant screening, given the potentially serious consequences from the transfer of allergies to a previously anergic recipient.

Original languageEnglish (US)
Pages (from-to)508-513
Number of pages6
JournalAnnals of hepatology
Volume18
Issue number3
DOIs
StatePublished - May 1 2019

Fingerprint

Peanut Hypersensitivity
Tissue Donors
Transplants
Liver
Hypersensitivity
Anaphylaxis
Contact Dermatitis
Carya
Corylus
Latent Tuberculosis
Alopecia Areata
Chemical and Drug Induced Liver Injury
Immediate Hypersensitivity
Pernicious Anemia
Butter
Pyridoxine
Food Hypersensitivity
Acute Liver Failure
Liver Function Tests
Isoniazid

Keywords

  • Acquired food allergy
  • IgE transfer
  • Rash in transplant recipient
  • Solid organ transplant
  • Transplant-acquired allergy

ASJC Scopus subject areas

  • Hepatology

Cite this

Transfer of peanut allergy from donor to recipient after liver transplant. / Aggarwal, Avin; Balogun, Rilwan; Carr, Tara F.; Desai, Archita; Jie, Tun; Pan, Jen Jung.

In: Annals of hepatology, Vol. 18, No. 3, 01.05.2019, p. 508-513.

Research output: Contribution to journalArticle

Aggarwal, Avin ; Balogun, Rilwan ; Carr, Tara F. ; Desai, Archita ; Jie, Tun ; Pan, Jen Jung. / Transfer of peanut allergy from donor to recipient after liver transplant. In: Annals of hepatology. 2019 ; Vol. 18, No. 3. pp. 508-513.
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