Transforming growth factor–β3 is required for secondary palate fusion

Gabriele Proetzel, Sharon A. Pawlowski, Michael V. Wiles, Moying Yin, Gregory P. Boivin, Philip N. Howles, Jixang Ding, Mark W.J. Ferguson, Thomas Doetschman

Research output: Contribution to journalArticle

710 Scopus citations

Abstract

Mice lacking TGF–β3 exhibit an incompletely penetrant failure of the palatal shelves to fuse leading to cleft palate. The defect appears to result from impaired adhesion of the apposing medial edge epithelia of the palatal shelves and subsequent elimination of the mid–line epithelial seam. No craniofacial abnormalities were observed. This result demonstrates that TGF–β3 affects palatal shelf fusion Dy an intrinsic, primary mechanism rather than by effects secondary to craniofacial defects.

Original languageEnglish (US)
Pages (from-to)409-414
Number of pages6
JournalNature Genetics
Volume11
Issue number4
DOIs
StatePublished - Dec 1995
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

Fingerprint Dive into the research topics of 'Transforming growth factor–β3 is required for secondary palate fusion'. Together they form a unique fingerprint.

  • Cite this

    Proetzel, G., Pawlowski, S. A., Wiles, M. V., Yin, M., Boivin, G. P., Howles, P. N., Ding, J., Ferguson, M. W. J., & Doetschman, T. (1995). Transforming growth factor–β3 is required for secondary palate fusion. Nature Genetics, 11(4), 409-414. https://doi.org/10.1038/ng1295-409