Transforming growth factor-β3 is required for secondary palate fusion

G. Proetzel, S. A. Pawlowski, M. V. Wiles, M. Yin, G. P. Boivin, P. N. Howles, J. Ding, M. W J Ferguson, Thomas C Doetschman

Research output: Contribution to journalArticle

702 Citations (Scopus)

Abstract

Mice lacking TGF-β3 exhibit an incompletely penetrant failure of the palatal shelves to fuse leading to cleft palate. The defect appears to result from impaired adhesion of the apposing medial edge epithelia of the palatal shelves and subsequent elimination of the mid-line epithelial seam. No craniofacial abnormalities were observed. This result demonstrates that TGF- β3 affects palatal shelf fusion by an intrinsic, primary mechanism rather than by effects secondary to craniofacial defects.

Original languageEnglish (US)
Pages (from-to)409-414
Number of pages6
JournalNature Genetics
Volume11
Issue number4
StatePublished - 1995
Externally publishedYes

Fingerprint

Craniofacial Abnormalities
Palate
Cleft Palate
Transforming Growth Factors
Epithelium

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Proetzel, G., Pawlowski, S. A., Wiles, M. V., Yin, M., Boivin, G. P., Howles, P. N., ... Doetschman, T. C. (1995). Transforming growth factor-β3 is required for secondary palate fusion. Nature Genetics, 11(4), 409-414.

Transforming growth factor-β3 is required for secondary palate fusion. / Proetzel, G.; Pawlowski, S. A.; Wiles, M. V.; Yin, M.; Boivin, G. P.; Howles, P. N.; Ding, J.; Ferguson, M. W J; Doetschman, Thomas C.

In: Nature Genetics, Vol. 11, No. 4, 1995, p. 409-414.

Research output: Contribution to journalArticle

Proetzel, G, Pawlowski, SA, Wiles, MV, Yin, M, Boivin, GP, Howles, PN, Ding, J, Ferguson, MWJ & Doetschman, TC 1995, 'Transforming growth factor-β3 is required for secondary palate fusion', Nature Genetics, vol. 11, no. 4, pp. 409-414.
Proetzel G, Pawlowski SA, Wiles MV, Yin M, Boivin GP, Howles PN et al. Transforming growth factor-β3 is required for secondary palate fusion. Nature Genetics. 1995;11(4):409-414.
Proetzel, G. ; Pawlowski, S. A. ; Wiles, M. V. ; Yin, M. ; Boivin, G. P. ; Howles, P. N. ; Ding, J. ; Ferguson, M. W J ; Doetschman, Thomas C. / Transforming growth factor-β3 is required for secondary palate fusion. In: Nature Genetics. 1995 ; Vol. 11, No. 4. pp. 409-414.
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