Transient receptor potential channels and caveolin-1: Good friends in tight spaces

Carmelle V. Remillard, Jason Yuan

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Caveolae formation has raised the concept of energy efficiency to new heights. The ultimate purpose of caveolae formation is to colocalize signaling proteins with membrane microdomains in order to facilitate their interaction and improve signal transduction efficiency. Although we know that the main structural protein of caveolae is caveolin, how caveolin interacts with membrane proteins to facilitate their integration into lipid raft domains is unclear. A caveolin-scaffolding domain (CSD) on caveolin itself can associate with membrane proteins such as G proteins and endothelial nitric oxide synthase. In this issue, Kwiatek et al. (p. 1174) report that the TRPC1 channel protein contains a C-terminal CSD-consensus binding sequence that allows for its physical and functional interaction with caveolin-1 in the caveolae of human pulmonary artery endothelial cells (PAEC). Competitive interaction with a CSD-conjugated peptide attenuates thrombin- and thapsigargin-induced Ca2+ influx via store-operated TRPC1 channels. Their data suggest that caveolin-1 can directly regulate TRPC1 function, extending its already ascribed role as a structural protein.

Original languageEnglish (US)
Pages (from-to)1151-1154
Number of pages4
JournalMolecular Pharmacology
Volume70
Issue number4
DOIs
StatePublished - 2006
Externally publishedYes

Fingerprint

Caveolins
Transient Receptor Potential Channels
Caveolin 1
Caveolae
Membrane Proteins
Proteins
Membrane Microdomains
Thapsigargin
Nitric Oxide Synthase Type III
Consensus Sequence
GTP-Binding Proteins
Thrombin
Pulmonary Artery
Signal Transduction
Endothelial Cells
Lipids

ASJC Scopus subject areas

  • Pharmacology

Cite this

Transient receptor potential channels and caveolin-1 : Good friends in tight spaces. / Remillard, Carmelle V.; Yuan, Jason.

In: Molecular Pharmacology, Vol. 70, No. 4, 2006, p. 1151-1154.

Research output: Contribution to journalArticle

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