Translational benchmark risk analysis

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Translational development - in the sense of translating a mature methodology from one area of application to another, evolving area - is discussed for the use of benchmark doses in quantitative risk assessment. Illustrations are presented with traditional applications of the benchmark paradigm in biology and toxicology, and also with risk endpoints that differ from traditional toxicological archetypes. It is seen that the benchmark approach can apply to a diverse spectrum of risk management settings. This suggests a promising future for this important risk-analytic tool. Extensions of the method to a wider variety of applications represent a significant opportunity for enhancing environmental, biomedical, industrial, and socio-economic risk assessments.

Original languageEnglish (US)
Pages (from-to)653-667
Number of pages15
JournalJournal of Risk Research
Volume13
Issue number5
DOIs
StatePublished - Jul 1 2010

Keywords

  • BMC
  • BMD
  • BMDL
  • benchmark concentration
  • benchmark dose
  • environmental biomonitoring
  • low-dose extrapolation
  • quantitative risk assessment
  • risk management
  • translational research
  • vulnerability assessment

ASJC Scopus subject areas

  • Safety, Risk, Reliability and Quality
  • Social Sciences(all)
  • Engineering(all)
  • Strategy and Management

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