Translational bioinformatics: Linking knowledge across biological and clinical realms

Indra Neil Sarkar, Atul J. Butte, Yves A. Lussier, Peter Tarczy-Hornoch, Lucila Ohno-Machado

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

Nearly a decade since the completion of the first draft of the human genome, the biomedical community is positioned to usher in a new era of scientific inquiry that links fundamental biological insights with clinical knowledge. Accordingly, holistic approaches are needed to develop and assess hypotheses that incorporate genotypic, phenotypic, and environmental knowledge. This perspective presents translational bioinformatics as a discipline that builds on the successes of bioinformatics and health informatics for the study of complex diseases. The early successes of translational bioinformatics are indicative of the potential to achieve the promise of the Human Genome Project for gaining deeper insights to the genetic underpinnings of disease and progress toward the development of a new generation of therapies.

Original languageEnglish (US)
Pages (from-to)354-357
Number of pages4
JournalJournal of the American Medical Informatics Association
Volume18
Issue number4
DOIs
StatePublished - Jul 1 2011
Externally publishedYes

ASJC Scopus subject areas

  • Health Informatics

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