Transplantation of the Hand, Face, and Composite Structures

Evolution and Current Status

Gordon R. Tobin, Warren C Breidenbach, Diane J. Pidwell, Suzanne T. Ildstad, Kadiyala V. Ravindra

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

This article reviews the world experience in the newly emerging field of composite tissue allotransplantation. These allografts contain multiple tissues that are usually musculoskeletal structures with a skin or epithelial surface, such as hand, facial structures, larynx, tongue, ear, knee/femur, abdominal wall, and penis. They represent a new transplantation field, with only a 10-year experience and just over 50 clinical cases. This review of the 10-year world experience found uniform technical success, immunologic biology, and immunosuppression regimens very similar to solid organ transplants, and success strongly correlated with adherence to guidelines for psychiatric screening, thorough preparation of patient and families, intense postoperative monitoring, and assurance of medication access. All failures reported have been caused by lapses in these parameters. This early experience shows a great potential for application of these new procedures to the most challenging reconstructive needs.

Original languageEnglish (US)
Pages (from-to)271-278
Number of pages8
JournalClinics in Plastic Surgery
Volume34
Issue number2
DOIs
StatePublished - Apr 2007
Externally publishedYes

Fingerprint

Vascularized Composite Allotransplantation
Hand Transplantation
Guideline Adherence
Penis
Abdominal Wall
Larynx
Tongue
Femur
Immunosuppression
Allografts
Ear
Psychiatry
Knee
Hand
Transplantation
Transplants
Skin

ASJC Scopus subject areas

  • Surgery

Cite this

Transplantation of the Hand, Face, and Composite Structures : Evolution and Current Status. / Tobin, Gordon R.; Breidenbach, Warren C; Pidwell, Diane J.; Ildstad, Suzanne T.; Ravindra, Kadiyala V.

In: Clinics in Plastic Surgery, Vol. 34, No. 2, 04.2007, p. 271-278.

Research output: Contribution to journalArticle

Tobin, Gordon R. ; Breidenbach, Warren C ; Pidwell, Diane J. ; Ildstad, Suzanne T. ; Ravindra, Kadiyala V. / Transplantation of the Hand, Face, and Composite Structures : Evolution and Current Status. In: Clinics in Plastic Surgery. 2007 ; Vol. 34, No. 2. pp. 271-278.
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