Transport of alkyl homologs across synthetic and biological membranes: A new model for chain length‐activity relationships

S. H. Yalkowsky, G. L. Flynn

Research output: Contribution to journalArticlepeer-review

51 Scopus citations

Abstract

The ability of each member of a biologically active homologous series to reach the receptor site can often be equated with its relative ability to permeate biological barriers. This paper presents a structure‐activity model based entirely on firmly established diffusional theories as well as solubility relationships generally applicable to aqueous systems. The equations derived and presented here were previously experimentally verified using synthetic membranes. These equations are generally applicable for transport across membranes and can be of use in describing a variety of passive absorption or permeation phenomena. Since true equilibrium is rarely attained in biological systems, a kinetic model provides an appropriate description of the physiological situation. Furthermore, a kinetic model offers considerable practical utility, because it can readily be incorporated into the overall pharmacokinetic treatment.

Original languageEnglish (US)
Pages (from-to)210-217
Number of pages8
JournalJournal of pharmaceutical sciences
Volume62
Issue number2
DOIs
StatePublished - Feb 1973
Externally publishedYes

Keywords

  • Chain length‐activity relationships—alkyl homolog transport across membranes
  • Membrane permeability, alkyl homologs—model for chain length‐activity relationships, equations
  • Structure‐activity relationships—model for transport of alkyl homologs across synthetic and biological membranes based on diffusion theories
  • Transport across synthetic and biological membranes—alkyl homologs, model for chain length‐activity relationships, equations

ASJC Scopus subject areas

  • Pharmaceutical Science

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