Transport of tracer albumin from peritoneum to plasma: Role of diaphragmatic, visceral, and parietal lymphatics

E. L.Rasheid Zakaria, Ole Simonsen, Anna Rippe, Bengt Rippe

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Using a technique to acutely seal off various parts of the peritoneal membrane surface, with or without evisceration, we investigated the role of diaphragmatic, visceral, and parietal peritoneal lymphatic pathways in the drainage of 125I-labeled albumin (RISA) from the peritoneal cavity to the plasma during acute peritoneal dialysis in artificially ventilated rats. The total RISA clearance out of the peritoneal cavity (Cl) as well as the portion of this Cl reaching the plasma per unit time (Cl→P) were assessed. Under non-steady-state conditions, the Cl was fivefold higher than the Cl→P. Evisceration caused a 25-30% reduction in both Cl→P and Cl. Sealing of the diaphragm, however, reduced the Cl→P by 55% without affecting the Cl. A further reduction in the Cl→P was obtained by combining sealing of the diaphragm with evisceration, which again markedly reduced the Cl. However, the greatest reduction in the Cl was obtained when the peritoneal surfaces of the anterior abdominal wall were sealed off in eviscerated rats. The discrepancy between the Cl and the Cl→P can be explained by the local entrance of fluid and macromolecules into periabdominal tissues, where fluid is rapidly absorbed through the capillary walls via the Starling forces, while macromolecules are accumulating due to their very slow uptake by tissue lymphatics under non-steady-state conditions. Of the portion of the total Cl that rapidly entered the plasma, conceivably by lymphatic absorption, 55% could be ascribed to diaphragmatic lymphatics, 30% to visceral lymphatics, and only seine 10-15% to parietal lymphatics.

Original languageEnglish (US)
Pages (from-to)H1549-H1556
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume270
Issue number5 39-5
DOIs
StatePublished - 1996
Externally publishedYes

Keywords

  • lymph flow
  • lymphatics
  • peritoneal dialysis
  • peritoneal physiology
  • peritoneal transport

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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