Trauma as an etiologic and aggravating factor in multiple sclerosis

Colin R. Bamford, William A. Sibley, Cole Thies, Jose F. Laguna, Michael S. Smith, Katherine Clark

Research output: Contribution to journalArticle

34 Scopus citations


We carried out a retrospective and prospective epidemiologic study designed to detect an association between trauma and multiple sclerosis in 130 patients and 82 age- and sex-matched controls. Electrical injury was followed by an increased frequency of exacerbation, which did not achieve statistical significance. There was no statistically significant association between other types of trauma and onset or deterioration of the disease. These findings do not prove that such an association cannot exist for any one individual patient; however, they do not provide evidence to support this idea.

Original languageEnglish (US)
Pages (from-to)1229-1234
Number of pages6
Issue number10
StatePublished - Oct 1981


ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Bamford, C. R., Sibley, W. A., Thies, C., Laguna, J. F., Smith, M. S., & Clark, K. (1981). Trauma as an etiologic and aggravating factor in multiple sclerosis. Neurology, 31(10), 1229-1234.