Treatment of chronic hypertension with intravenous enalaprilat and transdermal clonidine

M. A. Zawaideh, Burris R Duncan, M. W. Joseph, M. P. Dixit

Research output: Contribution to journalArticle

6 Scopus citations


We report an 11-year-old boy with hypertension and chronic intestinal pseudo-obstruction, which renders him totally dependent on parenteral nutrition and prevents the use of oral medications. Here we report the feasibility of utilizing chronic IV enalaprilat and transdermal clonidine on a chronic basis to control hypertension. Over the last 10 months, the patient's hypertension has been well controlled by 1.25 mg IV enalaprilat every 8 h and a 0.2-mg clonidine patch every 6 days, with no apparent side-effects. There are no reports of IV enalaprilat usage exceeding 3 weeks' duration. Therefore we believe that it is possible to effect reasonable management of chronic hypertension with the use of chronic IV enalaprilat and transdermal clonidine therapy.

Original languageEnglish (US)
Pages (from-to)85-86
Number of pages2
JournalPediatric Nephrology
Issue number1
Publication statusPublished - 2001



  • Angiotensin converting enzyme inhibitor
  • Chronic intestinal pseudo-obstruction
  • Chronic treatment
  • Enalaprilat
  • Hypertension
  • Intravenous route

ASJC Scopus subject areas

  • Nephrology
  • Pediatrics, Perinatology, and Child Health

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