Treatment of Depression in Medical Illness

Charles L Raison, David C. Purselle, Lucile Capuron, Andrew H. Miller

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

Depression is a common and potentially deadly concomitant of many medical illnesses. While the multiple psychological stressors associated with being sick have long been recognized as a risk factor for depression, increasing data indicate that activation of the pro-inflammatory cytokine network also directly contributes to mood disturbance in the medically ill. Moreover, recent studies using treatment with the cytokine interferon-alpha-2b (IFN-alpha) as a model system for immunebased depression indicate that depression in the medically ill may represent an amalgam of mood-specific and neurovegetative symptom clusters that are mediated by different neuroendocrine/neurotransmitter pathways. These findings provide novel insights into ongoing diagnostic controversies created by the striking symptom overlap between major depression and sickness and have clear implications for the pharmacological treatment of depressive syndromes in patients with medical illnesses.

Original languageEnglish (US)
Title of host publicationBiology of Depression: From Novel Insights to Therapeutic Strategies
PublisherJohn Wiley and Sons
Pages253-278
Number of pages26
ISBN (Print)3527307850, 9783527307852
DOIs
StatePublished - Jan 29 2008
Externally publishedYes

Fingerprint

Depression
interferon alfa-2b
Cytokines
Therapeutics
Depressive Disorder
Neurotransmitter Agents
Pharmacology
Psychology

Keywords

  • Disease
  • Medical illness
  • Parkinson's
  • Sick
  • Treatment

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Raison, C. L., Purselle, D. C., Capuron, L., & Miller, A. H. (2008). Treatment of Depression in Medical Illness. In Biology of Depression: From Novel Insights to Therapeutic Strategies (pp. 253-278). John Wiley and Sons. https://doi.org/10.1002/9783527619672.ch9

Treatment of Depression in Medical Illness. / Raison, Charles L; Purselle, David C.; Capuron, Lucile; Miller, Andrew H.

Biology of Depression: From Novel Insights to Therapeutic Strategies. John Wiley and Sons, 2008. p. 253-278.

Research output: Chapter in Book/Report/Conference proceedingChapter

Raison, CL, Purselle, DC, Capuron, L & Miller, AH 2008, Treatment of Depression in Medical Illness. in Biology of Depression: From Novel Insights to Therapeutic Strategies. John Wiley and Sons, pp. 253-278. https://doi.org/10.1002/9783527619672.ch9
Raison CL, Purselle DC, Capuron L, Miller AH. Treatment of Depression in Medical Illness. In Biology of Depression: From Novel Insights to Therapeutic Strategies. John Wiley and Sons. 2008. p. 253-278 https://doi.org/10.1002/9783527619672.ch9
Raison, Charles L ; Purselle, David C. ; Capuron, Lucile ; Miller, Andrew H. / Treatment of Depression in Medical Illness. Biology of Depression: From Novel Insights to Therapeutic Strategies. John Wiley and Sons, 2008. pp. 253-278
@inbook{eb629a7003634de0abec5a429c346906,
title = "Treatment of Depression in Medical Illness",
abstract = "Depression is a common and potentially deadly concomitant of many medical illnesses. While the multiple psychological stressors associated with being sick have long been recognized as a risk factor for depression, increasing data indicate that activation of the pro-inflammatory cytokine network also directly contributes to mood disturbance in the medically ill. Moreover, recent studies using treatment with the cytokine interferon-alpha-2b (IFN-alpha) as a model system for immunebased depression indicate that depression in the medically ill may represent an amalgam of mood-specific and neurovegetative symptom clusters that are mediated by different neuroendocrine/neurotransmitter pathways. These findings provide novel insights into ongoing diagnostic controversies created by the striking symptom overlap between major depression and sickness and have clear implications for the pharmacological treatment of depressive syndromes in patients with medical illnesses.",
keywords = "Disease, Medical illness, Parkinson's, Sick, Treatment",
author = "Raison, {Charles L} and Purselle, {David C.} and Lucile Capuron and Miller, {Andrew H.}",
year = "2008",
month = "1",
day = "29",
doi = "10.1002/9783527619672.ch9",
language = "English (US)",
isbn = "3527307850",
pages = "253--278",
booktitle = "Biology of Depression: From Novel Insights to Therapeutic Strategies",
publisher = "John Wiley and Sons",

}

TY - CHAP

T1 - Treatment of Depression in Medical Illness

AU - Raison, Charles L

AU - Purselle, David C.

AU - Capuron, Lucile

AU - Miller, Andrew H.

PY - 2008/1/29

Y1 - 2008/1/29

N2 - Depression is a common and potentially deadly concomitant of many medical illnesses. While the multiple psychological stressors associated with being sick have long been recognized as a risk factor for depression, increasing data indicate that activation of the pro-inflammatory cytokine network also directly contributes to mood disturbance in the medically ill. Moreover, recent studies using treatment with the cytokine interferon-alpha-2b (IFN-alpha) as a model system for immunebased depression indicate that depression in the medically ill may represent an amalgam of mood-specific and neurovegetative symptom clusters that are mediated by different neuroendocrine/neurotransmitter pathways. These findings provide novel insights into ongoing diagnostic controversies created by the striking symptom overlap between major depression and sickness and have clear implications for the pharmacological treatment of depressive syndromes in patients with medical illnesses.

AB - Depression is a common and potentially deadly concomitant of many medical illnesses. While the multiple psychological stressors associated with being sick have long been recognized as a risk factor for depression, increasing data indicate that activation of the pro-inflammatory cytokine network also directly contributes to mood disturbance in the medically ill. Moreover, recent studies using treatment with the cytokine interferon-alpha-2b (IFN-alpha) as a model system for immunebased depression indicate that depression in the medically ill may represent an amalgam of mood-specific and neurovegetative symptom clusters that are mediated by different neuroendocrine/neurotransmitter pathways. These findings provide novel insights into ongoing diagnostic controversies created by the striking symptom overlap between major depression and sickness and have clear implications for the pharmacological treatment of depressive syndromes in patients with medical illnesses.

KW - Disease

KW - Medical illness

KW - Parkinson's

KW - Sick

KW - Treatment

UR - http://www.scopus.com/inward/record.url?scp=38649091537&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38649091537&partnerID=8YFLogxK

U2 - 10.1002/9783527619672.ch9

DO - 10.1002/9783527619672.ch9

M3 - Chapter

AN - SCOPUS:38649091537

SN - 3527307850

SN - 9783527307852

SP - 253

EP - 278

BT - Biology of Depression: From Novel Insights to Therapeutic Strategies

PB - John Wiley and Sons

ER -