Treatment of Fungal Meningitis With Miconazole

Stanley C. Deresinski, Ralph B. Lilly, H. B. Levine, John N Galgiani, David A. Stevens

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Twelve patients with fungal meningitis (ten cases were due to Coccidioides immitis, two were from Cryptococcus neoformans) were treated with brief courses of intravenous (IV) miconazole. Eleven patients, including patients with severe, chronic disease, had been treated unsuccessfully with amphotericin B. Four patients also received miconazole injected directly into the CSF. The drug was well tolerated by any route, with mild reversible side effects. After IV administration the miconazole concentration in the CSF rarely exceeded the minimal inhibitory concentration (MIC) of the infecting organism. Intra-CSF administration of 20 mg generally produced levels above the MIC for 24 hours. Five of ten patients with coccidioidal meningitis responded clinically. Of these five, four received only IV miconazole; three relapsed after therapy was stopped. Miconazole appears promising as a treatment of fungal meningitis, but trials of longer duration might prevent relapse.

Original languageEnglish (US)
Pages (from-to)1180-1185
Number of pages6
JournalArchives of Internal Medicine
Volume137
Issue number9
DOIs
StatePublished - 1977
Externally publishedYes

ASJC Scopus subject areas

  • Internal Medicine

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