Treatment of Goodpasture syndrome with cyclophosphamide, prednisone and plasma exchange transfusions

R. D. Rossen, J. Duffy, K. B. McCredie, M. A. Reisberg, J. T. Sharp, E. M. Hersh, G. Eknoyan, W. N. Suki

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Repeated plasma exchanges were performed in a 44 year old man with Goodpasture syndrome, also treated with cyclophosphamide and prednisone. Improvement was observed within 3 weeks of starting the protocol, and by the 76th week, endogenous creatinine clearance had increased from 30 to 56 ml/min/1.73 M 2 and serum albumin from 2.7 to 3.7 g/dl. Prior treatment with immunosuppressive drugs had not significantly influenced circulating antibody levels. But sustained suppression of antibody was achieved after the plasma exchanges were begun, suggesting that physical removal of circulating antibody combined with antiproliferative drug treatment may be a useful way to control undesirable humoral immune responses.

Original languageEnglish (US)
Pages (from-to)218-222
Number of pages5
JournalClinical and Experimental Immunology
Volume24
Issue number1
StatePublished - Dec 1 1976

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Treatment of Goodpasture syndrome with cyclophosphamide, prednisone and plasma exchange transfusions'. Together they form a unique fingerprint.

  • Cite this

    Rossen, R. D., Duffy, J., McCredie, K. B., Reisberg, M. A., Sharp, J. T., Hersh, E. M., Eknoyan, G., & Suki, W. N. (1976). Treatment of Goodpasture syndrome with cyclophosphamide, prednisone and plasma exchange transfusions. Clinical and Experimental Immunology, 24(1), 218-222.