Treatment of Goodpasture syndrome with cyclophosphamide, prednisone and plasma exchange transfusions

R. D. Rossen, J. Duffy, K. B. McCredie, M. A. Reisberg, J. T. Sharp, Evan M Hersh, G. Eknoyan, W. N. Suki

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Repeated plasma exchanges were performed in a 44 year old man with Goodpasture syndrome, also treated with cyclophosphamide and prednisone. Improvement was observed within 3 weeks of starting the protocol, and by the 76th week, endogenous creatinine clearance had increased from 30 to 56 ml/min/1.73 M 2 and serum albumin from 2.7 to 3.7 g/dl. Prior treatment with immunosuppressive drugs had not significantly influenced circulating antibody levels. But sustained suppression of antibody was achieved after the plasma exchanges were begun, suggesting that physical removal of circulating antibody combined with antiproliferative drug treatment may be a useful way to control undesirable humoral immune responses.

Original languageEnglish (US)
Pages (from-to)218-222
Number of pages5
JournalClinical and Experimental Immunology
Volume24
Issue number1
StatePublished - 1976
Externally publishedYes

Fingerprint

Anti-Glomerular Basement Membrane Disease
Plasma Exchange
Prednisone
Cyclophosphamide
Antibodies
Immunosuppressive Agents
Humoral Immunity
Serum Albumin
Pharmaceutical Preparations
Creatinine
Therapeutics

ASJC Scopus subject areas

  • Immunology

Cite this

Rossen, R. D., Duffy, J., McCredie, K. B., Reisberg, M. A., Sharp, J. T., Hersh, E. M., ... Suki, W. N. (1976). Treatment of Goodpasture syndrome with cyclophosphamide, prednisone and plasma exchange transfusions. Clinical and Experimental Immunology, 24(1), 218-222.

Treatment of Goodpasture syndrome with cyclophosphamide, prednisone and plasma exchange transfusions. / Rossen, R. D.; Duffy, J.; McCredie, K. B.; Reisberg, M. A.; Sharp, J. T.; Hersh, Evan M; Eknoyan, G.; Suki, W. N.

In: Clinical and Experimental Immunology, Vol. 24, No. 1, 1976, p. 218-222.

Research output: Contribution to journalArticle

Rossen, RD, Duffy, J, McCredie, KB, Reisberg, MA, Sharp, JT, Hersh, EM, Eknoyan, G & Suki, WN 1976, 'Treatment of Goodpasture syndrome with cyclophosphamide, prednisone and plasma exchange transfusions', Clinical and Experimental Immunology, vol. 24, no. 1, pp. 218-222.
Rossen, R. D. ; Duffy, J. ; McCredie, K. B. ; Reisberg, M. A. ; Sharp, J. T. ; Hersh, Evan M ; Eknoyan, G. ; Suki, W. N. / Treatment of Goodpasture syndrome with cyclophosphamide, prednisone and plasma exchange transfusions. In: Clinical and Experimental Immunology. 1976 ; Vol. 24, No. 1. pp. 218-222.
@article{145f6c777050488db78795b2cd703063,
title = "Treatment of Goodpasture syndrome with cyclophosphamide, prednisone and plasma exchange transfusions",
abstract = "Repeated plasma exchanges were performed in a 44 year old man with Goodpasture syndrome, also treated with cyclophosphamide and prednisone. Improvement was observed within 3 weeks of starting the protocol, and by the 76th week, endogenous creatinine clearance had increased from 30 to 56 ml/min/1.73 M 2 and serum albumin from 2.7 to 3.7 g/dl. Prior treatment with immunosuppressive drugs had not significantly influenced circulating antibody levels. But sustained suppression of antibody was achieved after the plasma exchanges were begun, suggesting that physical removal of circulating antibody combined with antiproliferative drug treatment may be a useful way to control undesirable humoral immune responses.",
author = "Rossen, {R. D.} and J. Duffy and McCredie, {K. B.} and Reisberg, {M. A.} and Sharp, {J. T.} and Hersh, {Evan M} and G. Eknoyan and Suki, {W. N.}",
year = "1976",
language = "English (US)",
volume = "24",
pages = "218--222",
journal = "Clinical and Experimental Immunology",
issn = "0009-9104",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Treatment of Goodpasture syndrome with cyclophosphamide, prednisone and plasma exchange transfusions

AU - Rossen, R. D.

AU - Duffy, J.

AU - McCredie, K. B.

AU - Reisberg, M. A.

AU - Sharp, J. T.

AU - Hersh, Evan M

AU - Eknoyan, G.

AU - Suki, W. N.

PY - 1976

Y1 - 1976

N2 - Repeated plasma exchanges were performed in a 44 year old man with Goodpasture syndrome, also treated with cyclophosphamide and prednisone. Improvement was observed within 3 weeks of starting the protocol, and by the 76th week, endogenous creatinine clearance had increased from 30 to 56 ml/min/1.73 M 2 and serum albumin from 2.7 to 3.7 g/dl. Prior treatment with immunosuppressive drugs had not significantly influenced circulating antibody levels. But sustained suppression of antibody was achieved after the plasma exchanges were begun, suggesting that physical removal of circulating antibody combined with antiproliferative drug treatment may be a useful way to control undesirable humoral immune responses.

AB - Repeated plasma exchanges were performed in a 44 year old man with Goodpasture syndrome, also treated with cyclophosphamide and prednisone. Improvement was observed within 3 weeks of starting the protocol, and by the 76th week, endogenous creatinine clearance had increased from 30 to 56 ml/min/1.73 M 2 and serum albumin from 2.7 to 3.7 g/dl. Prior treatment with immunosuppressive drugs had not significantly influenced circulating antibody levels. But sustained suppression of antibody was achieved after the plasma exchanges were begun, suggesting that physical removal of circulating antibody combined with antiproliferative drug treatment may be a useful way to control undesirable humoral immune responses.

UR - http://www.scopus.com/inward/record.url?scp=0017227138&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017227138&partnerID=8YFLogxK

M3 - Article

C2 - 949874

AN - SCOPUS:0017227138

VL - 24

SP - 218

EP - 222

JO - Clinical and Experimental Immunology

JF - Clinical and Experimental Immunology

SN - 0009-9104

IS - 1

ER -