Treatment of hepatic failure with ex vivo pig-liver perfusion followed by liver transplantation

Ravi S. Chari, Bradley H. Collins, John C. Magee, J. Michael Dimaio, Allan D. Kirk, Robert C. Harland, Richard L. Mccann, Jeffrey L. Platt, William C. Meyers

Research output: Contribution to journalArticle

236 Citations (Scopus)

Abstract

In 1990, more than 27,000 patients died of liver failure in the United States1. Perfusion through a liver from another person or a member of another species, such as a monkey, outside the body was used in the past to stabilize the condition of some patients with acute or subacute liver failure25. Few patients survived, however, and this approach was superseded by orthotopic liver transplantation6. Liver transplantation is associated with higher mortality for patients with fulminant hepatic failure than for patients with chronic liver disease, however. Patients with fulminant hepatic failure often have multiorgan failure and.

Original languageEnglish (US)
Pages (from-to)234-237
Number of pages4
JournalNew England Journal of Medicine
Volume331
Issue number4
DOIs
StatePublished - Jul 28 1994
Externally publishedYes

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Liver Failure
Treatment Failure
Liver Transplantation
Swine
Perfusion
Liver
Acute Liver Failure
Haplorhini
Liver Diseases
Chronic Disease
Mortality

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Treatment of hepatic failure with ex vivo pig-liver perfusion followed by liver transplantation. / Chari, Ravi S.; Collins, Bradley H.; Magee, John C.; Dimaio, J. Michael; Kirk, Allan D.; Harland, Robert C.; Mccann, Richard L.; Platt, Jeffrey L.; Meyers, William C.

In: New England Journal of Medicine, Vol. 331, No. 4, 28.07.1994, p. 234-237.

Research output: Contribution to journalArticle

Chari, RS, Collins, BH, Magee, JC, Dimaio, JM, Kirk, AD, Harland, RC, Mccann, RL, Platt, JL & Meyers, WC 1994, 'Treatment of hepatic failure with ex vivo pig-liver perfusion followed by liver transplantation', New England Journal of Medicine, vol. 331, no. 4, pp. 234-237. https://doi.org/10.1056/NEJM199407283310404
Chari, Ravi S. ; Collins, Bradley H. ; Magee, John C. ; Dimaio, J. Michael ; Kirk, Allan D. ; Harland, Robert C. ; Mccann, Richard L. ; Platt, Jeffrey L. ; Meyers, William C. / Treatment of hepatic failure with ex vivo pig-liver perfusion followed by liver transplantation. In: New England Journal of Medicine. 1994 ; Vol. 331, No. 4. pp. 234-237.
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