Treatment of malignant brain tumors with focused ultrasound hyperthermia and radiation: results of a phase I trial

A. N. Guthkelch, L. P. Carter, J. R. Cassady, K. H. Hynynen, R. P. Iacono, P. C. Johnson, E. A.M.T. Obbens, R. B. Roemer, J. F. Seeger, D. S. Shimm, B. Steal

Research output: Contribution to journalArticlepeer-review

115 Scopus citations

Abstract

Hyperthermia delivered by scanned focused ultrasound was combined with external beam radiation to treat 15 patients with primary malignant tumors of the brain. A preliminary craniectomy was performed to avoid attenuation of the ultrasound beam by the skull, and multiple thermal sensors were employed to ascertain intratumoral temperatures. The target temperature was 42.5°C at the tumor boundary. This was attained at more than one point during every complete treatment, while a mean temperature in excess of 42°C was achieved within the scanned tumor volume during at least 1 treatment in 11 patients. Technical problems and toxicities are described.

Original languageEnglish (US)
Pages (from-to)271-284
Number of pages14
JournalJournal of Neuro-Oncology
Volume10
Issue number3
DOIs
StatePublished - Jun 1 1991

Keywords

  • brain tumor oncology
  • glioblastoma multiforme
  • hyperthermia
  • radiation therapy
  • ultrasound

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research

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