TY - JOUR
T1 - Treatment of multiple myeloma in remission with anticancer drugs having cell cycle specific characteristics
AU - Alberts, D. S.
AU - Durie, B. G.M.
AU - Salmon, S. E.
PY - 1977/12/1
Y1 - 1977/12/1
N2 - Four anticancer drugs with cell cycle phase-specific characteristics (azathioprine, cytosine arabinoside, hydroxyurea, and vincristine) were individually used to treat 12 patients with multiple myeloma in partial remission (i.e., ≥ 50% reduction in tumor cell number) after cell cycle nonspecific chemotherapy. In six of eight patients vincristine induced further statistically significant reductions in total body myeloma cell number (24%-60% tumor cell reductions), whereas, azathioprine had lesser activity. Cytosine arabinoside and hydroxyurea were unsuccessful and excessively toxic chemotherapeutic agents in this setting, although optimal dosing schedules were difficult to achieve because they caused moderately severe bone marrow suppression. We conclude that vincristine is a useful cytoreductive agent for multiple myeloma and should be added to cell cycle nonspecific agents for the treatment of this disease.
AB - Four anticancer drugs with cell cycle phase-specific characteristics (azathioprine, cytosine arabinoside, hydroxyurea, and vincristine) were individually used to treat 12 patients with multiple myeloma in partial remission (i.e., ≥ 50% reduction in tumor cell number) after cell cycle nonspecific chemotherapy. In six of eight patients vincristine induced further statistically significant reductions in total body myeloma cell number (24%-60% tumor cell reductions), whereas, azathioprine had lesser activity. Cytosine arabinoside and hydroxyurea were unsuccessful and excessively toxic chemotherapeutic agents in this setting, although optimal dosing schedules were difficult to achieve because they caused moderately severe bone marrow suppression. We conclude that vincristine is a useful cytoreductive agent for multiple myeloma and should be added to cell cycle nonspecific agents for the treatment of this disease.
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M3 - Article
C2 - 872138
AN - SCOPUS:0017687304
VL - 61
SP - 381
EP - 388
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
SN - 0027-8874
IS - 3
ER -