Treatment of nonmetastatic gestational trophoblastic disease with oral methotrexate

James F. Barter, Seng Jaw Soong, Kenneth D. Hatch, James W. Orr, Edward C. Partridge, J. Maxwell Austin, Hugh M. Shingleton

Research output: Contribution to journalArticle

19 Scopus citations


Fifteen patients with nonmetastatic gestational trophoblastic disease were treated solely with methotrexate given orally rather than intramuscularly. Remission, defined as a ti-human chorionic gonadotropin titer of <5 mlU/ml for 3 consecutive weeks, was attained in 13 (87%) of the 15 patients. Level of toxicity was acceptable. Patient comfort, convenience, and less time off work and in the physician's office are significant advantages to this efficacious, well-tolerated method of therapy.

Original languageEnglish (US)
Pages (from-to)1166-1168
Number of pages3
JournalAmerican journal of obstetrics and gynecology
Issue number5
StatePublished - Jan 1 1987
Externally publishedYes



  • Gestational trophoblastic disease
  • oral methotrexate

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Barter, J. F., Soong, S. J., Hatch, K. D., Orr, J. W., Partridge, E. C., Austin, J. M., & Shingleton, H. M. (1987). Treatment of nonmetastatic gestational trophoblastic disease with oral methotrexate. American journal of obstetrics and gynecology, 157(5), 1166-1168.