Treatment of Pseudomonas keratitis by continuous infusion of topical antibiotics with the Morgan Lens

Mingwu Wang, Whitney A. Smith, Joshua K. Duncan, Joseph M Miller

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Purpose: Despite following standard treatment, Pseudomonas keratitis can continue to progress and result in loss of vision or of the eye. Our cases demonstrate that the Morgan Lens can be an effective topical antibiotic delivery vehicle in advanced keratitis. Methods: Two patients (3 eyes) with Pseudomonas keratitis were included in this report after failing to respond to intense inpatient topical treatment. Because loss of the eyes was imminent, the Morgan Lenses were used for continuous lavage with ceftazidime (50 mg/mL), in conjunction with other conventional treatment. Results: Three days after lavage, corneal cultures became negative in all eyes. Infusion was continued for at least a week to ensure sterilization of the infection before switching to standard topical therapy. The infection in both cases was promptly eradicated and the eyes were rescued. Conclusions: The Morgan Lens can be a viable alternative in treating severe and aggressive infectious keratitis or sclerokeratitis. Application of the Morgan Lens is noninvasive and requires minimal training. Intravenous tubing connectors allow for easy swapping between medications, simultaneous administration of multiple medications, and titration of dosing. Additionally, it is costeffective as the low demand for nursing care essentially eliminates the need for intensive care unit admission.

Original languageEnglish (US)
Pages (from-to)617-620
Number of pages4
JournalCornea
Volume36
Issue number5
DOIs
StatePublished - 2017

Keywords

  • Antibiotic lavage
  • Morgan Lens
  • Pseudomonas aeruginosa keratitis

ASJC Scopus subject areas

  • Ophthalmology

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