Treatment of refractory ITP and Evans syndrome by haematopoietic cell transplantation: Is it indicated, and for whom?

J. E. Vaughn, Faiz - Anwer, H. J. Deeg

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Several lines of therapy have been established for patients with immune thrombocytopenia (ITP) and Evans syndrome. However, these therapies generally require prolonged administration, lead to profound immunosuppression and increased infectious risk, and are often poorly tolerated. While most patients with these disorders will respond to first-line steroid therapy, others will prove refractory or intolerant to multiple treatments. In these patients (and possibly even selected patients who are not considered refractory), autologous or allogeneic haematopoietic stem cell transplantation (HCT) may provide definitive therapy. We review the literature on the treatment of ITP and Evans syndrome with HCT and discuss its use in the management of these disorders. We also pose, for the purpose of discussion, research questions that will be important to address if HCT is to be considered a viable option for more patients with these diseases.

Original languageEnglish (US)
Pages (from-to)5-11
Number of pages7
JournalVox Sanguinis
Volume110
Issue number1
DOIs
StatePublished - Jan 1 2016

Keywords

  • Evans syndrome
  • Haematopoietic cell transplantation
  • Immune thrombocytopenia
  • Refractory

ASJC Scopus subject areas

  • Hematology

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