Triple stimulus-responsive polypeptide nanoparticles that enhance intratumoral spatial distribution

Daniel J. Callahan, Wenge Liu, Xinghai Li, Matthew R. Dreher, Wafa Hassouneh, Minkyu Kim, Piotr Marszalek, Ashutosh Chilkoti

Research output: Contribution to journalArticle

69 Scopus citations

Abstract

To address the limited tumor penetration of nanoparticle drug delivery vehicles, we report the first pH-responsive polypeptide micelle that dissociates at the low extracellular pH of solid tumors. This histidine-rich elastin-like polypeptide block copolymer self-assembles at 37 °C into spherical micelles that are stabilized by Zn and are disrupted as the pH drops from 7.4 to 6.4. These pH-sensitive micelles demonstrate better in vivo penetration and distribution in tumors than a pH-insensitive control.

Original languageEnglish (US)
Pages (from-to)2165-2170
Number of pages6
JournalNano Letters
Volume12
Issue number4
DOIs
StatePublished - Apr 11 2012
Externally publishedYes

Keywords

  • Polypeptides
  • block copolymers
  • pH responsive
  • stimulus-responsive
  • tumor drug delivery

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

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  • Cite this

    Callahan, D. J., Liu, W., Li, X., Dreher, M. R., Hassouneh, W., Kim, M., Marszalek, P., & Chilkoti, A. (2012). Triple stimulus-responsive polypeptide nanoparticles that enhance intratumoral spatial distribution. Nano Letters, 12(4), 2165-2170. https://doi.org/10.1021/nl300630c