Triptans disrupt brain networks and promote stress-induced CSD-like responses in cortical and subcortical areas

L. Becerra, J. Bishop, G. Barmettler, Y. Xie, E. Navratilova, Frank Porreca, D. Borsook

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A number of drugs, including triptans, promote migraine chronification in susceptible individuals. In rats, a period of triptan administration over 7 days can produce “latent sensitization” (14 days after discontinuation of drug) demonstrated as enhanced sensitivity to presumed migraine triggers such as environmental stress and lowered threshold for electrically induced cortical spreading depression (CSD). Here we have used fMRI to evaluate the early changes in brain networks at day 7 of sumatriptan administration that may induce latent sensitization as well as the potential response to stress. After continuous infusion of sumatriptan, rats were scanned to measure changes in resting state networks and the response to bright light environmental stress. Rats receiving sumatriptan, but not saline infusion, showed significant differences in default mode, autonomic, basal ganglia, salience, and sensorimotor networks. Bright light stress produced CSD-like responses in sumatriptan-treated but not control rats. Our data show the first brain-related changes in a rat model of medication overuse headache and suggest that this approach could be used to evaluate the multiple brain networks involved that may promote this condition.

Original languageEnglish (US)
Pages (from-to)208-217
Number of pages10
JournalJournal of Neurophysiology
Volume115
Issue number1
DOIs
StatePublished - Oct 21 2015

Fingerprint

Cortical Spreading Depression
Tryptamines
Sumatriptan
Brain
Migraine Disorders
Secondary Headache Disorders
Autonomic Ganglia
Light
Basal Ganglia
Pharmaceutical Preparations
Magnetic Resonance Imaging

Keywords

  • Chronic dosing
  • Cortical spreading depression
  • FMRI
  • Pain
  • Sumatriptan

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)

Cite this

Triptans disrupt brain networks and promote stress-induced CSD-like responses in cortical and subcortical areas. / Becerra, L.; Bishop, J.; Barmettler, G.; Xie, Y.; Navratilova, E.; Porreca, Frank; Borsook, D.

In: Journal of Neurophysiology, Vol. 115, No. 1, 21.10.2015, p. 208-217.

Research output: Contribution to journalArticle

Becerra, L. ; Bishop, J. ; Barmettler, G. ; Xie, Y. ; Navratilova, E. ; Porreca, Frank ; Borsook, D. / Triptans disrupt brain networks and promote stress-induced CSD-like responses in cortical and subcortical areas. In: Journal of Neurophysiology. 2015 ; Vol. 115, No. 1. pp. 208-217.
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