Troubleshooting molecular phylogenetic analyses

Michael Sanderson, H. Bradley Shaffer

Research output: Contribution to journalArticle

219 Citations (Scopus)

Abstract

The number, size, and scope of phylogenetic analyses using molecular data has increased steadily in recent years. This has simultaneously led to a dramatic improvement in our understanding of phylogenetic relationships and a better appreciation for an array of methodological problems that continue to hinder progress in phylogenetic studies of certain data sets and/or particular parts of the tree of life. This review focuses on several persistent problems, including rooting, conflict among data sets, weak support in trees, strong but evidently incorrect support, and the computational issues arising when methods are applied to the large data sets that are becoming increasingly commonplace. We frame each of these issues as a specific problem to be overcome, review the relevant theoretical and empirical literature, and suggest solutions, or at least strategies, for further investigation of the issues involved.

Original languageEnglish (US)
Pages (from-to)49-72
Number of pages24
JournalAnnual Review of Ecology and Systematics
Volume33
DOIs
StatePublished - 2002
Externally publishedYes

Fingerprint

phylogenetics
phylogeny
rooting
methodology
conflict
method

Keywords

  • Algorithm
  • Data partition
  • Long-branch attraction
  • Model
  • Rooting

ASJC Scopus subject areas

  • Ecology

Cite this

Troubleshooting molecular phylogenetic analyses. / Sanderson, Michael; Shaffer, H. Bradley.

In: Annual Review of Ecology and Systematics, Vol. 33, 2002, p. 49-72.

Research output: Contribution to journalArticle

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