TRP channels in hypertension

Amy L. Firth, Carmelle V. Remillard, Jason X.J. Yuan

Research output: Contribution to journalReview articlepeer-review

90 Scopus citations

Abstract

Pulmonary and systemic arterial hypertension are associated with profound alterations in Ca2+ homeostasis and smooth muscle cell proliferation. A novel class of non-selective cation channels, the transient receptor potential (TRP) channels, have emerged at the forefront of research into hypertensive disease states. TRP channels are identified as molecular correlates for receptor-operated and store-operated cation channels in the vasculature. Over 10 TRP isoforms are identified at the mRNA and protein expression levels in the vasculature. Current research implicates upregulation of specific TRP isoforms to be associated with increased Ca2+ influx, characteristic of vasoconstriction and vascular smooth muscle cell proliferation. TRP channels are implicated as Ca2+ entry pathways in pulmonary hypertension and essential hypertension. Caveolae have recently emerged as membrane microdomains in which TRP channels may be co-localized with the endoplasmic reticulum in both smooth muscle and endothelial cells. Such enhanced expression and function of TRP channels and their localization in caveolae in pathophysiological hypertensive disease states highlights their importance as potential targets for pharmacological intervention.

Original languageEnglish (US)
Pages (from-to)895-906
Number of pages12
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Volume1772
Issue number8
DOIs
StatePublished - Aug 2007

Keywords

  • Ca
  • Essential hypertension
  • Proliferation
  • Pulmonary arterial hypertension
  • Transient receptor potential channels

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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