True-lumen collapse in aortic dissection. Part I. Evaluation of causative factors in phantoms with pulsatile flow

Jin Wook Chung, Christopher Elkins, Toyohiko Sakai, Noriyuki Kato, Thomas Vestring, Charles P. Semba, Suzanne M. Slonim, Michael D. Dake

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

PURPOSE: To investigate the causative factors in true-lumen collapse in a model of aortic dissection. MATERIALS AND METHODS: Phantoms with an aortic arch, true and false lumina with abdominal branch vessels, and a distal bifurcation were used to model a Stanford type B aortic dissection. The effects of anatomic factors (entry-tear size, branch-vessel flow distribution, fenestrations, distal reentry communication) and physiologic factors (peripheral resistance in the branch vessels, pump output and rate, vascular compliance) on true-lumen collapse were investigated. The morphology of the true lumen was observed. Branch pressures and flow rates were measured. RESULTS: True-lumen collapse was induced and was exacerbated by an increase in the size of the entry tear, a decrease in the false-lumen outflow caused by occluding the false-lumen branch vessels, and an increase in the true-lumen outflow caused by lowering the peripheral resistance in true-lumen branch vessels. Two kinds of true-lumen collapse depended on pump output. With low pump output and low outflow resistance from the true lumen, the true lumen collapsed. With high pump output and low inflow resistance in the false lumen, the true lumen was compressed. Distal reentry communication between the true and false limbs was more effective than aortic fenestrations in preventing true-lumen collapse. CONCLUSION: True-lumen collapse in this dissection model strongly depends on the difference in the rations of inflow capacity to outflow capacity in the true and false lumina. Both anatomic and physiologic factors can affect true-lumen collapse.

Original languageEnglish (US)
Pages (from-to)87-98
Number of pages12
JournalRadiology
Volume214
Issue number1
DOIs
StatePublished - Jan 1 2000
Externally publishedYes

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Pulsatile Flow
Dissection
Tears
Vascular Resistance
Thoracic Aorta
Compliance
Blood Vessels
Extremities
Pressure

Keywords

  • Aorta, dissection
  • Aorta, flow dynamics
  • Aorta, stenosis or obstruction
  • Aorta, US
  • Phantoms

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

True-lumen collapse in aortic dissection. Part I. Evaluation of causative factors in phantoms with pulsatile flow. / Chung, Jin Wook; Elkins, Christopher; Sakai, Toyohiko; Kato, Noriyuki; Vestring, Thomas; Semba, Charles P.; Slonim, Suzanne M.; Dake, Michael D.

In: Radiology, Vol. 214, No. 1, 01.01.2000, p. 87-98.

Research output: Contribution to journalArticle

Chung, Jin Wook ; Elkins, Christopher ; Sakai, Toyohiko ; Kato, Noriyuki ; Vestring, Thomas ; Semba, Charles P. ; Slonim, Suzanne M. ; Dake, Michael D. / True-lumen collapse in aortic dissection. Part I. Evaluation of causative factors in phantoms with pulsatile flow. In: Radiology. 2000 ; Vol. 214, No. 1. pp. 87-98.
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AU - Elkins, Christopher

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AU - Kato, Noriyuki

AU - Vestring, Thomas

AU - Semba, Charles P.

AU - Slonim, Suzanne M.

AU - Dake, Michael D.

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N2 - PURPOSE: To investigate the causative factors in true-lumen collapse in a model of aortic dissection. MATERIALS AND METHODS: Phantoms with an aortic arch, true and false lumina with abdominal branch vessels, and a distal bifurcation were used to model a Stanford type B aortic dissection. The effects of anatomic factors (entry-tear size, branch-vessel flow distribution, fenestrations, distal reentry communication) and physiologic factors (peripheral resistance in the branch vessels, pump output and rate, vascular compliance) on true-lumen collapse were investigated. The morphology of the true lumen was observed. Branch pressures and flow rates were measured. RESULTS: True-lumen collapse was induced and was exacerbated by an increase in the size of the entry tear, a decrease in the false-lumen outflow caused by occluding the false-lumen branch vessels, and an increase in the true-lumen outflow caused by lowering the peripheral resistance in true-lumen branch vessels. Two kinds of true-lumen collapse depended on pump output. With low pump output and low outflow resistance from the true lumen, the true lumen collapsed. With high pump output and low inflow resistance in the false lumen, the true lumen was compressed. Distal reentry communication between the true and false limbs was more effective than aortic fenestrations in preventing true-lumen collapse. CONCLUSION: True-lumen collapse in this dissection model strongly depends on the difference in the rations of inflow capacity to outflow capacity in the true and false lumina. Both anatomic and physiologic factors can affect true-lumen collapse.

AB - PURPOSE: To investigate the causative factors in true-lumen collapse in a model of aortic dissection. MATERIALS AND METHODS: Phantoms with an aortic arch, true and false lumina with abdominal branch vessels, and a distal bifurcation were used to model a Stanford type B aortic dissection. The effects of anatomic factors (entry-tear size, branch-vessel flow distribution, fenestrations, distal reentry communication) and physiologic factors (peripheral resistance in the branch vessels, pump output and rate, vascular compliance) on true-lumen collapse were investigated. The morphology of the true lumen was observed. Branch pressures and flow rates were measured. RESULTS: True-lumen collapse was induced and was exacerbated by an increase in the size of the entry tear, a decrease in the false-lumen outflow caused by occluding the false-lumen branch vessels, and an increase in the true-lumen outflow caused by lowering the peripheral resistance in true-lumen branch vessels. Two kinds of true-lumen collapse depended on pump output. With low pump output and low outflow resistance from the true lumen, the true lumen collapsed. With high pump output and low inflow resistance in the false lumen, the true lumen was compressed. Distal reentry communication between the true and false limbs was more effective than aortic fenestrations in preventing true-lumen collapse. CONCLUSION: True-lumen collapse in this dissection model strongly depends on the difference in the rations of inflow capacity to outflow capacity in the true and false lumina. Both anatomic and physiologic factors can affect true-lumen collapse.

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