Tryptic peptide map analyses of mouse transplantation antigens

Florence Lafay, Sandra J. Ewald, Minnie McMillan, Jeffrey A. Frelinger, Leroy Hood

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Tryptic peptide map analyses of five K- and three D-gene products of various H-2 haplotypes are presented. These data support earlier sequence studies and demonstrate that the variations in allelic gene products of the K or D loci are scattered throughout much of the polypeptide chains. Furthermore, the K allelic gene products are no more closely related to one another than they are to the D allelic gene products. This apparent lack of K-ness and D-ness places interesting constraints on the genetic organization and evolutionary history of the genes encoding the transplantation antigens.

Original languageEnglish (US)
Pages (from-to)21-32
Number of pages12
JournalImmunogenetics
Volume12
Issue number1
DOIs
StatePublished - Dec 1981
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Genetics

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