Tryptophan-containing 1,5-tetrazole dipeptide analogs: Synthesis of Trpψ[CN4]Nle as a cis amide bond surrogate.

Lakmal W. Boteju, Victor J. Hruby

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Abstract

The 1,5-disubstituted tetrazole dipeptide analog Z-Trp(NinZ)ψ[CN4]Nle-OBzl was synthesized in good yield and high optical purity using a modified procedure of Zabrocki et al. This dipeptide analog can be selectively deprotected at either the N or the C terminal for further incorporation into peptides.

Original languageEnglish (US)
Pages (from-to)1757-1760
Number of pages4
JournalTetrahedron Letters
Volume34
Issue number11
DOIs
StatePublished - Mar 12 1993

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ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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