Tryptophan depletion and risk of depression relapse: A prospective study of tryptophan depletion as a potential predictor of depressive episodes

Francisco Moreno, George R. Heninger, Cynthia A. McGahuey, Pedro L. Delgado

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

Background: This study investigated the relationship between depressive symptom response during tryptophan depletion and future depressive episodes. Methods: Twelve subjects with prior major depressive episodes in remission and medication-free for ≥3 months (patients), and 12 matched healthy (control) subjects received two tryptophan depletion tests 1 week apart. During follow-up the Hamilton Depression Rating Scale was administered weekly for 1 month, monthly for 3 months, and once at 6 and 12 months. Results: With results from both tests, tryptophan depletion has a sensitivity of 78%, specificity of 80%, positive predictive value of 70%, and negative predictive value of 86% to identify future depressive episodes. Survival analysis shows that mood response to tryptophan depletion reliably predicts major depressive episodes during the follow-up year (r = .2725, p = .014). Conclusions: Tryptophan depletion may be clinically useful in identifying individuals at risk for future major depressive episodes. (C) 2000 Society of Biological Psychiatry.

Original languageEnglish (US)
Pages (from-to)327-329
Number of pages3
JournalBiological Psychiatry
Volume48
Issue number4
DOIs
StatePublished - Aug 15 2000

Fingerprint

Tryptophan
Prospective Studies
Depression
Recurrence
Survival Analysis
Healthy Volunteers
Sensitivity and Specificity

Keywords

  • Depletion paradigm
  • Major depression
  • Serotonin
  • Vulnerability

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Tryptophan depletion and risk of depression relapse : A prospective study of tryptophan depletion as a potential predictor of depressive episodes. / Moreno, Francisco; Heninger, George R.; McGahuey, Cynthia A.; Delgado, Pedro L.

In: Biological Psychiatry, Vol. 48, No. 4, 15.08.2000, p. 327-329.

Research output: Contribution to journalArticle

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