Tryptophan fluorescence of cells and tissue in esophageal carcinoma

Bhaskar Banerjee, Logan R. Graves, Urs Utzinger

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Cancer is a cellular process. The emission spectrum of tryptophan, which produces the strongest fluorescence in cells, was investigated in cells and tissues of a normal and malignant esophagus. Estimated fluorescence intensity per cell was about three times greater in cancerous cells than in normal cells. The fluorescence was also greater in cancerous tissue but the difference was attenuated, probably because of absorption and scattering. Cellular fluorescence from tryptophan may be useful for the detection of cancer in esophageal cells and tissues.

Original languageEnglish (US)
Article number6264078
Pages (from-to)3273-3274
Number of pages2
JournalIEEE Sensors Journal
Volume12
Issue number11
DOIs
StatePublished - Oct 26 2012

Keywords

  • Autofluorescence
  • cancer
  • tryptophan

ASJC Scopus subject areas

  • Instrumentation
  • Electrical and Electronic Engineering

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