Tuberculosis in the 1990s: Resurgence, regimens, and resources

Research output: Contribution to journalArticle

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Abstract

Physicians in the United States must maintain vigilance for the 25 000 annual new cases of tuberculosis, concentrated in the elderly, in immigrants, in migrant and minority populations, and in immunosuppressed patients. Tuberculosis rates in the South remain above the national average. Physicians diagnosing tuberculosis may also treat the disease, working with health departments, which can assist with drugs, follow-up tests, and contact investigation. Powerful short-course regimens have been standard treatments since 1986. The preferred combination is isoniazid, rifampin, and pyrazinamide daily for 2 months, followed by isoniazid and rifampin for 4 more months. A 9-month regimen of isoniazid and rifampin is equally effective. Supplementation or extension of these regimens is mandatory when drug resistance or immunosuppression, respectively, is likely. Isoniazid prophylaxis for 6 to 12 months continues to be a vital but often neglected preventive measure for those infected with Mycobacterium tuberculosis, but without active disease.

Original languageEnglish (US)
Pages (from-to)584-593
Number of pages10
JournalSouthern Medical Journal
Volume85
Issue number6
StatePublished - 1992

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Isoniazid
Tuberculosis
Rifampin
Physicians
Pyrazinamide
Mycobacterium tuberculosis
Drug Resistance
Immunosuppression
Health
Pharmaceutical Preparations
Population
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Tuberculosis in the 1990s : Resurgence, regimens, and resources. / Pust, Ronald E.

In: Southern Medical Journal, Vol. 85, No. 6, 1992, p. 584-593.

Research output: Contribution to journalArticle

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