Tumor cell dormancy induced by p38SAPK and ER-stress signaling: An adaptive advantage for metastatic cells?

Aparna C. Ranganathan, Alejandro P. Adam, Lin Zhang, Julio A. Aguirre-Ghiso

Research output: Contribution to journalReview articlepeer-review

59 Scopus citations

Abstract

The mechanisms that determine whether a tumor cell that has disseminated to a secondary site will resume growth immediately, die or enter a state of dormancy are poorly understood. Although tumor dormancy represents a common clinical finding, studying the mechanisms behind this stage of tumor progression has been challenging. Furthermore, it is thought that dormant tumor cells are refractory to chemotherapy due to their lack of proliferation. However, whether this is the only reason for their chemo-resistance remains to be proven. In this review we summarize recent findings that provide a mechanistic explanation about how stress signaling through the p38SAPK pathway and ER-stress signaling may coordinate the induction of growth arrest and drug-resistance in a model of squamous carcinoma dormancy. We further discuss how dormant tumor cells may enter this stage to adapt to strenuous conditions that do not favor immediate growth after dissemination. Finally, we propose that this response may recapitulate an evolutionarily conserved program of life-span extension through adaptation and tolerance to stress.

Original languageEnglish (US)
Pages (from-to)729-735
Number of pages7
JournalCancer Biology and Therapy
Volume5
Issue number7
DOIs
StatePublished - Jul 2006

Keywords

  • Growth arrest
  • Metastasis
  • PERK
  • Stress signaling
  • Survival
  • Tumor dormancy
  • p38

ASJC Scopus subject areas

  • Molecular Medicine
  • Oncology
  • Pharmacology
  • Cancer Research

Fingerprint Dive into the research topics of 'Tumor cell dormancy induced by p38<sup>SAPK</sup> and ER-stress signaling: An adaptive advantage for metastatic cells?'. Together they form a unique fingerprint.

Cite this