Tumor-Induced Osteomalacia: Evidence of a Surgically Correctable Alteration in Vitamin D Metabolism

Mitchell S. Parker, Daniel H. Mintz, Irwin Klein, Mark R. Haussler

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

A 15-year-old boy was treated for nonfamilial hypophosphatemic rickets. Treatment with ergocalciferol, 100,000 units/day, and phosphorus, 2 to 4 g/day, failed to alleviate the rickets. Levels of 1α,25-dihydroxyvitamin D were low while levels of 25-hydroxyvitamin D were elevated. After removal of a benign fibroma, the level of 1α,25-dihydroxyvitamin D increased, the serum phosphorus level became normal, and the osteomalacia was cured. The alteration of vitamin D metabolism and associated hypophosphatemia in oncogenic osteomalacia is a potentially reversible cause of bone disease mediated by the tumor.

Original languageEnglish (US)
Pages (from-to)492-493
Number of pages2
JournalJAMA: The Journal of the American Medical Association
Volume245
Issue number5
DOIs
StatePublished - Feb 6 1981

ASJC Scopus subject areas

  • Medicine(all)

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