Tumor necrosis factor-α and interleukin-1β in cerebrospinal fluid of patients with coccidioidal meningitis during therapy with fluconazole

Neil M. Ampel, D. R. Ahmann, K. L. Delgado, John N Galgiani, G. A. Cloud

Research output: Contribution to journalArticle

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Abstract

The levels of tumor necrosis factor-α (TNF-α) and interleukin (IL)-1β in the cerebrospinal fluid (CSF) of 66 patients with coccidioidal meningitis during therapy with fluconazole were measured by ELISA. The median concentration of TNF-α was 15.2 pg/mL for 322 samples; for IL-1β, it was 4.7 pg/mL for 316 samples. There were no significant changes in the level of either cytokine over 24 months of follow-up nor was there an association between the initial CSF concentrations of TNF-α and IL-1β and subsequent fluconazole treatment failure. Over time, concentrations of IL-1β were significantly associated with both clinical symptoms and white blood cell counts in CSF. These results indicate that CSF levels of TNF-α and IL-1β are relatively low compared with those associated with acute bacterial meningitis.

Original languageEnglish (US)
Pages (from-to)1675-1678
Number of pages4
JournalJournal of Infectious Diseases
Volume171
Issue number6
StatePublished - 1995

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Fluconazole
Interleukin-1
Meningitis
Cerebrospinal Fluid
Tumor Necrosis Factor-alpha
Therapeutics
Bacterial Meningitides
Treatment Failure
Leukocyte Count
Enzyme-Linked Immunosorbent Assay
Cytokines

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

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Tumor necrosis factor-α and interleukin-1β in cerebrospinal fluid of patients with coccidioidal meningitis during therapy with fluconazole. / Ampel, Neil M.; Ahmann, D. R.; Delgado, K. L.; Galgiani, John N; Cloud, G. A.

In: Journal of Infectious Diseases, Vol. 171, No. 6, 1995, p. 1675-1678.

Research output: Contribution to journalArticle

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