Tumor necrosis factor- and interleukin-1 in cerebrospinal fluid of patients with coccidioidal meningitis during therapy with fluconazole

Neil M. Ampel, Derek R. Ahmann, Kathy L. Delgado, John N. Galgiani, Gretchen A. Cloud

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The levels of tumor necrosis factor-α (TNF-α) and interleukin (IL)-1β in the cerebrospinal fluid (CSF) of 66 patients with coccidioidal meningitis during therapy with fluconazole were measured by ELISA. The median concentration of TNF-α was 15.2 pg/ml, for 322 samples; for IL-1β, it was 4.7 pg/ml, for 316 samples. There were no significant changes in the level of either cytokine over 24 months of follow-up nor was there an association between the initial CSF concentrations of TNF-α and IL-1β and subsequent fluconazole treatment failure. Over time, concentrations of IL-1β were significantly associated with both clinical symptoms and white blood cell counts in CSF. These results indicate that CSF levels of TNF-α and IL-1β are relatively low compared with those associated with acute bacterial meningitis.

Original languageEnglish (US)
Pages (from-to)1675-1678
Number of pages4
JournalJournal of Infectious Diseases
Volume171
Issue number6
DOIs
StatePublished - Jun 1995

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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