Tumor protein translationally controlled 1 is a p53 target gene that promotes cell survival

Weiming Chen, Huihui Wang, Shasha Tao, Yi Zheng, Wei Wu, Fangru Lian, Melba Jaramillo, Deyu Fang, Donna Zhang

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Tumor suppressor p53 maintains genome stability by differentially activating target genes that control diverse cellular responses, such as the antioxidant response, cell cycle arrest and apoptosis. Despite the fact that many p53 downstream genes have been well characterized, novel p53 target genes are continuously being identified. Here, we report that Tpt1 is a direct target gene of p53. We found that p53 upregulates the transcription of Tpt1 and identified a p53-responsive element in the promoter of the mouse Tpt1 gene. Furthermore, p53-dependent induction of Tpt1 was able to reduce oxidative stress, minimize apoptosis, and promote cell survival in response to H 2O2 challenge. In addition, a positive correlation between the expression of p53 and Tpt1 only existed in normal lung tissues, not in lung tumors. Such positive correlation was also found in lung cell lines that contain wild-type p53, but not mutated p53. Based on the important role of Tpt1 in cancer development, chemoresistance, and cancer reversion, identification of Tpt1 as a direct target gene of p53 not only adds to the complexity of the p53 network, but may also open up a new avenue for cancer prevention and intervention.

Original languageEnglish (US)
Pages (from-to)2321-2328
Number of pages8
JournalCell Cycle
Volume12
Issue number14
DOIs
StatePublished - Jul 15 2013

Fingerprint

p53 Genes
Cell Survival
Neoplasms
Lung
Apoptosis
Genomic Instability
Cell Cycle Checkpoints
Genes
Oxidative Stress
Up-Regulation
Antioxidants
translationally-controlled 1 tumor protein
Cell Line

Keywords

  • Cancer
  • P53
  • TCTP
  • Tpt1

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Developmental Biology

Cite this

Tumor protein translationally controlled 1 is a p53 target gene that promotes cell survival. / Chen, Weiming; Wang, Huihui; Tao, Shasha; Zheng, Yi; Wu, Wei; Lian, Fangru; Jaramillo, Melba; Fang, Deyu; Zhang, Donna.

In: Cell Cycle, Vol. 12, No. 14, 15.07.2013, p. 2321-2328.

Research output: Contribution to journalArticle

Chen, W, Wang, H, Tao, S, Zheng, Y, Wu, W, Lian, F, Jaramillo, M, Fang, D & Zhang, D 2013, 'Tumor protein translationally controlled 1 is a p53 target gene that promotes cell survival', Cell Cycle, vol. 12, no. 14, pp. 2321-2328. https://doi.org/10.4161/cc.25404
Chen, Weiming ; Wang, Huihui ; Tao, Shasha ; Zheng, Yi ; Wu, Wei ; Lian, Fangru ; Jaramillo, Melba ; Fang, Deyu ; Zhang, Donna. / Tumor protein translationally controlled 1 is a p53 target gene that promotes cell survival. In: Cell Cycle. 2013 ; Vol. 12, No. 14. pp. 2321-2328.
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