Tumor reccurrence and survival in stage IB cancer of the cervix

Hugh M. Shingleton, Hazel Gore, Seng Jaw Soong, James W. Orr, Kenneth D Hatch, JM Max Austin, Edward E. Partridge

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Clinical records of 371 women with carcinoma of the cervix, Stage IB, treated in the decade 1969-1979 were reviewed. Cancer recurred in 67 women (18.1%). A group of 171 patients treated by radiation, including 25 who were surgically staged prior to treatment, was compared to 200 patients treated by radical abdominal hysterectomy and pelvic node dissection, including 35 who had postoperative whole pelvis radiation. A multifactorial analysis included time to recurrence, site of recurrence, treatment for recurrence, and survival after recurrence. Pathology review and clinicopathological correlation included tumor configuration, histologic type, size of tumor in greatest dimension, and rate of node metastases in patients undergoing either radical hysterectomy or surgical staging procedures. Lesion size was found to be the most accurate predictor of disease-free survival; this was true whether the patient was treated by surgery or radiation and was not significantly affected by the tumor histology. Nodal metastases were associated with increasing size of lesions and predicted high recurrence rates. Node metastasis rates were not affected by the histology of the tumor.

Original languageEnglish (US)
Pages (from-to)265-272
Number of pages8
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Volume6
Issue number3
Publication statusPublished - 1983
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Shingleton, H. M., Gore, H., Soong, S. J., Orr, J. W., Hatch, K. D., Austin, JM. M., & Partridge, E. E. (1983). Tumor reccurrence and survival in stage IB cancer of the cervix. American Journal of Clinical Oncology: Cancer Clinical Trials, 6(3), 265-272.