Tuning the molecular giant titin through phosphorylation: Role in health and disease

Carlos Hidalgo, Henk Granzier

Research output: Contribution to journalReview article

64 Scopus citations

Abstract

Titin is a giant multi-functional filament that spans half of the sarcomere. Titin's extensible I-band region functions as a molecular spring that provides passive stiffness to cardiac myocytes. Elevated diastolic stiffness is found in a large fraction of heart failure patients and thus understanding the normal mechanisms and pathophysiology of passive stiffness modulation is clinically important. Here we provide first a brief general background on titin including what is known about titin isoforms and then focus on recently discovered post-translational modifications of titin that alter passive stiffness. We discuss the various kinases that have been shown to phosphorylate titin and address the possible roles of titin phosphorylation in cardiac disease, including heart failure with preserved ejection fraction (HFpEF).

Original languageEnglish (US)
Pages (from-to)165-171
Number of pages7
JournalTrends in Cardiovascular Medicine
Volume23
Issue number5
DOIs
StatePublished - Jul 1 2013

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Tuning the molecular giant titin through phosphorylation: Role in health and disease'. Together they form a unique fingerprint.

  • Cite this