Two ABC transporter operons and the antimicrobial resistance gene mtrF are pilT responsive in Neisseria gonorrhoeae

Alexandra Friedrich, Cindy G. Arvidson, William M. Shafer, Eun Hee Lee, Magdalene "Maggie" So

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Retraction of type IV pili is mediated by PilT. We show that loss of pilT function leads to upregulation of mtrF (multiple transferable resistance) and two operons encoding putative ABC transporters in Neisseria gonorrhoeae MS11. This effect occurs indirectly through the transcriptional regulator FarR, which until now has been shown to regulate only farAB. L-Glutamine can reverse pilT downregulation of the ABC transporter operons and mtrF.

Original languageEnglish (US)
Pages (from-to)5399-5402
Number of pages4
JournalJournal of Bacteriology
Volume189
Issue number14
DOIs
StatePublished - Jul 2007

Fingerprint

ATP-Binding Cassette Transporters
Neisseria gonorrhoeae
Operon
Glutamine
Genes
Up-Regulation
Down-Regulation

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Immunology

Cite this

Two ABC transporter operons and the antimicrobial resistance gene mtrF are pilT responsive in Neisseria gonorrhoeae. / Friedrich, Alexandra; Arvidson, Cindy G.; Shafer, William M.; Lee, Eun Hee; So, Magdalene "Maggie".

In: Journal of Bacteriology, Vol. 189, No. 14, 07.2007, p. 5399-5402.

Research output: Contribution to journalArticle

Friedrich, Alexandra ; Arvidson, Cindy G. ; Shafer, William M. ; Lee, Eun Hee ; So, Magdalene "Maggie". / Two ABC transporter operons and the antimicrobial resistance gene mtrF are pilT responsive in Neisseria gonorrhoeae. In: Journal of Bacteriology. 2007 ; Vol. 189, No. 14. pp. 5399-5402.
@article{f6bd0ab3ee4b4b47a2bcca2d818d1e3c,
title = "Two ABC transporter operons and the antimicrobial resistance gene mtrF are pilT responsive in Neisseria gonorrhoeae",
abstract = "Retraction of type IV pili is mediated by PilT. We show that loss of pilT function leads to upregulation of mtrF (multiple transferable resistance) and two operons encoding putative ABC transporters in Neisseria gonorrhoeae MS11. This effect occurs indirectly through the transcriptional regulator FarR, which until now has been shown to regulate only farAB. L-Glutamine can reverse pilT downregulation of the ABC transporter operons and mtrF.",
author = "Alexandra Friedrich and Arvidson, {Cindy G.} and Shafer, {William M.} and Lee, {Eun Hee} and So, {Magdalene {"}Maggie{"}}",
year = "2007",
month = "7",
doi = "10.1128/JB.00300-07",
language = "English (US)",
volume = "189",
pages = "5399--5402",
journal = "Journal of Bacteriology",
issn = "0021-9193",
publisher = "American Society for Microbiology",
number = "14",

}

TY - JOUR

T1 - Two ABC transporter operons and the antimicrobial resistance gene mtrF are pilT responsive in Neisseria gonorrhoeae

AU - Friedrich, Alexandra

AU - Arvidson, Cindy G.

AU - Shafer, William M.

AU - Lee, Eun Hee

AU - So, Magdalene "Maggie"

PY - 2007/7

Y1 - 2007/7

N2 - Retraction of type IV pili is mediated by PilT. We show that loss of pilT function leads to upregulation of mtrF (multiple transferable resistance) and two operons encoding putative ABC transporters in Neisseria gonorrhoeae MS11. This effect occurs indirectly through the transcriptional regulator FarR, which until now has been shown to regulate only farAB. L-Glutamine can reverse pilT downregulation of the ABC transporter operons and mtrF.

AB - Retraction of type IV pili is mediated by PilT. We show that loss of pilT function leads to upregulation of mtrF (multiple transferable resistance) and two operons encoding putative ABC transporters in Neisseria gonorrhoeae MS11. This effect occurs indirectly through the transcriptional regulator FarR, which until now has been shown to regulate only farAB. L-Glutamine can reverse pilT downregulation of the ABC transporter operons and mtrF.

UR - http://www.scopus.com/inward/record.url?scp=34447508305&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34447508305&partnerID=8YFLogxK

U2 - 10.1128/JB.00300-07

DO - 10.1128/JB.00300-07

M3 - Article

C2 - 17496077

AN - SCOPUS:34447508305

VL - 189

SP - 5399

EP - 5402

JO - Journal of Bacteriology

JF - Journal of Bacteriology

SN - 0021-9193

IS - 14

ER -