Two ABC transporter operons and the antimicrobial resistance gene mtrF are pilT responsive in Neisseria gonorrhoeae

Alexandra Friedrich, Cindy G. Arvidson, William M. Shafer, Eun Hee Lee, Magdalene So

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Retraction of type IV pili is mediated by PilT. We show that loss of pilT function leads to upregulation of mtrF (multiple transferable resistance) and two operons encoding putative ABC transporters in Neisseria gonorrhoeae MS11. This effect occurs indirectly through the transcriptional regulator FarR, which until now has been shown to regulate only farAB. L-Glutamine can reverse pilT downregulation of the ABC transporter operons and mtrF.

Original languageEnglish (US)
Pages (from-to)5399-5402
Number of pages4
JournalJournal of bacteriology
Volume189
Issue number14
DOIs
StatePublished - Jul 1 2007

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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