Two bioactive pterocarpans from Erythrina burana

Ermias Dagne, A. A.Leslie Gunatilaka, David G.I. Kingston, Melaku Alemu, Glenn Hofmann, Randall K. Johnson

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

Bioactivity-directed fractionation of the CHCl3 extract of the bark of Erythrina burana afforded phaseollidin [1] and cristacarpin [2]. Both 1 and 2 exhibited moderate but selective activity towards DNA repair-deficient yeast mutants, whereas only 1 was found to be cytotoxic. 13C-nmr spectra of both compounds were assigned.

Original languageEnglish (US)
Pages (from-to)1831-1834
Number of pages4
JournalJournal Of Natural Products
Volume56
Issue number10
DOIs
StatePublished - Oct 1993

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ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this

Dagne, E., Gunatilaka, A. A. L., Kingston, D. G. I., Alemu, M., Hofmann, G., & Johnson, R. K. (1993). Two bioactive pterocarpans from Erythrina burana. Journal Of Natural Products, 56(10), 1831-1834. https://doi.org/10.1021/np50100a028