Two bioactive pterocarpans from Erythrina burana

Ermias Dagne, Leslie Gunatilaka, David G I Kingston, Melaku Alemu, Glenn Hofmann, Randall K. Johnson

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Bioactivity-directed fractionation of the CHCl3 extract of the bark of Erythrina burana afforded phaseollidin [1] and cristacarpin [2]. Both 1 and 2 exhibited moderate but selective activity towards DNA repair-deficient yeast mutants, whereas only 1 was found to be cytotoxic. 13C-nmr spectra of both compounds were assigned.

Original languageEnglish (US)
Pages (from-to)1831-1834
Number of pages4
JournalJournal of Natural Products
Volume56
Issue number10
StatePublished - 1993
Externally publishedYes

Fingerprint

Pterocarpans
Erythrina
DNA Repair-Deficiency Disorders
Fractionation
DNA repair
Bioactivity
Yeast
fractionation
bark
Repair
Yeasts
yeasts
mutants
DNA
extracts
cristacarpin
phaseollidin

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Dagne, E., Gunatilaka, L., Kingston, D. G. I., Alemu, M., Hofmann, G., & Johnson, R. K. (1993). Two bioactive pterocarpans from Erythrina burana. Journal of Natural Products, 56(10), 1831-1834.

Two bioactive pterocarpans from Erythrina burana. / Dagne, Ermias; Gunatilaka, Leslie; Kingston, David G I; Alemu, Melaku; Hofmann, Glenn; Johnson, Randall K.

In: Journal of Natural Products, Vol. 56, No. 10, 1993, p. 1831-1834.

Research output: Contribution to journalArticle

Dagne, E, Gunatilaka, L, Kingston, DGI, Alemu, M, Hofmann, G & Johnson, RK 1993, 'Two bioactive pterocarpans from Erythrina burana', Journal of Natural Products, vol. 56, no. 10, pp. 1831-1834.
Dagne E, Gunatilaka L, Kingston DGI, Alemu M, Hofmann G, Johnson RK. Two bioactive pterocarpans from Erythrina burana. Journal of Natural Products. 1993;56(10):1831-1834.
Dagne, Ermias ; Gunatilaka, Leslie ; Kingston, David G I ; Alemu, Melaku ; Hofmann, Glenn ; Johnson, Randall K. / Two bioactive pterocarpans from Erythrina burana. In: Journal of Natural Products. 1993 ; Vol. 56, No. 10. pp. 1831-1834.
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