Two new cytotoxic cytochalasins from Xylaria obovata

Ermias Dagne, Leslie Gunatilaka, Senait Asmellash, Dawit Abate, David G I Kingston, Glenn A. Hofmann, Randall K. Johnson

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Two new cytotoxic cytochalasins were isolated by brine shrimp bioassay-guided fractionation from a culture of the wood inhabiting fungus, Xylaria obovata. Their structures were determined as 19,20-epoxycytochalasin Q (1) and its deacetyl analog 2 by the application of spectroscopic techniques and chemical correlation with cytochalasin R. Acetylation of 2 yielded 1. Both 1 and 2 were cytotoxic but were found to be inactive in an HIV-protease inhibitory assay and a mechanism-based DNA damaging yeast assay.

Original languageEnglish (US)
Pages (from-to)5615-5620
Number of pages6
JournalTetrahedron
Volume50
Issue number19
DOIs
StatePublished - 1994
Externally publishedYes

Fingerprint

Cytochalasins
Assays
HIV Protease
Artemia
Acetylation
Bioassay
Fractionation
Fungi
Biological Assay
Yeast
Wood
Yeasts
DNA
brine
19,20-epoxycytochalasin Q

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Dagne, E., Gunatilaka, L., Asmellash, S., Abate, D., Kingston, D. G. I., Hofmann, G. A., & Johnson, R. K. (1994). Two new cytotoxic cytochalasins from Xylaria obovata. Tetrahedron, 50(19), 5615-5620. https://doi.org/10.1016/S0040-4020(01)85632-5

Two new cytotoxic cytochalasins from Xylaria obovata. / Dagne, Ermias; Gunatilaka, Leslie; Asmellash, Senait; Abate, Dawit; Kingston, David G I; Hofmann, Glenn A.; Johnson, Randall K.

In: Tetrahedron, Vol. 50, No. 19, 1994, p. 5615-5620.

Research output: Contribution to journalArticle

Dagne, E, Gunatilaka, L, Asmellash, S, Abate, D, Kingston, DGI, Hofmann, GA & Johnson, RK 1994, 'Two new cytotoxic cytochalasins from Xylaria obovata', Tetrahedron, vol. 50, no. 19, pp. 5615-5620. https://doi.org/10.1016/S0040-4020(01)85632-5
Dagne E, Gunatilaka L, Asmellash S, Abate D, Kingston DGI, Hofmann GA et al. Two new cytotoxic cytochalasins from Xylaria obovata. Tetrahedron. 1994;50(19):5615-5620. https://doi.org/10.1016/S0040-4020(01)85632-5
Dagne, Ermias ; Gunatilaka, Leslie ; Asmellash, Senait ; Abate, Dawit ; Kingston, David G I ; Hofmann, Glenn A. ; Johnson, Randall K. / Two new cytotoxic cytochalasins from Xylaria obovata. In: Tetrahedron. 1994 ; Vol. 50, No. 19. pp. 5615-5620.
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