Two new cytotoxic cytochalasins from Xylaria obovata

Ermias Dagne, A. A.Leslie Gunatilaka, Senait Asmellash, Dawit Abate, David G.I. Kingston, Glenn A. Hofmann, Randall K. Johnson

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

Two new cytotoxic cytochalasins were isolated by brine shrimp bioassay-guided fractionation from a culture of the wood inhabiting fungus, Xylaria obovata. Their structures were determined as 19,20-epoxycytochalasin Q (1) and its deacetyl analog 2 by the application of spectroscopic techniques and chemical correlation with cytochalasin R. Acetylation of 2 yielded 1. Both 1 and 2 were cytotoxic but were found to be inactive in an HIV-protease inhibitory assay and a mechanism-based DNA damaging yeast assay.

Original languageEnglish (US)
Pages (from-to)5615-5620
Number of pages6
JournalTetrahedron
Volume50
Issue number19
DOIs
StatePublished - 1994

    Fingerprint

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Dagne, E., Gunatilaka, A. A. L., Asmellash, S., Abate, D., Kingston, D. G. I., Hofmann, G. A., & Johnson, R. K. (1994). Two new cytotoxic cytochalasins from Xylaria obovata. Tetrahedron, 50(19), 5615-5620. https://doi.org/10.1016/S0040-4020(01)85632-5