Two polyamine analogs (BE-4-4-4 and BE-4-4-4-4) directly affect growth, survival, and cell cycle progression in two human brain tumor cell lines

Christophe J. Bergeron, Hirak S. Basu, Laurence J. Marton, Dennis F. Deen, Malgorzata Pellarin, Burt G. Feuerstein

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

1,14-Bis-(ethyl)-amino-5,10-diazatetradecane N1, N11-bis(ethyl)norspermine (BE-4-4-4) and 1,19-bis-(ethylamino)-5,10,15 triazanonadecane (BE-4-4-4-4) are two relatively new polyamine analogs synthesized for use as antineoplastic agents. In human brain tumor cell lines U-251 MG and SF-767, both agents inhibited cell growth, were cytotoxic, induced a variable G1/S block, and depleted intracellular polyamines. Since intracellular polyamine depletion did not always correlate with growth inhibition, cell survival, or cell cycle progression, it cannot completely explain the effects of these agents on growth, survival, and cell cycle progression in U-251 MG and SF-767 cells.

Original languageEnglish (US)
Pages (from-to)411-417
Number of pages7
JournalCancer Chemotherapy And Pharmacology
Volume36
Issue number5
DOIs
StatePublished - Sep 1995

Keywords

  • Cell cycle
  • Glioma
  • Polyamine analogs

ASJC Scopus subject areas

  • Oncology
  • Toxicology
  • Pharmacology
  • Cancer Research
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Two polyamine analogs (BE-4-4-4 and BE-4-4-4-4) directly affect growth, survival, and cell cycle progression in two human brain tumor cell lines'. Together they form a unique fingerprint.

  • Cite this