Two-step solution-phase synthesis of novel quinoxalinones utilizing a UDC (Ugi/de-Boc/cyclize) strategy

Thomas Nixey, Paul Tempest, Christopher Hulme

Research output: Contribution to journalArticle

74 Scopus citations

Abstract

The novel solution-phase synthesis of an array of biologically relevant quinoxalinones in a simple two-step procedure is revealed. Transformations are carried out in excellent yield by condensation of mono-Boc protected ortho-phenylene di-amine, glyoxylic acids and supporting Ugi reagents. Subsequent acid treatment and evaporation affords quinoxalinones in good to excellent yields.

Original languageEnglish (US)
Pages (from-to)1637-1639
Number of pages3
JournalTetrahedron Letters
Volume43
Issue number9
DOIs
StatePublished - Feb 25 2002
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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