Two-step solution-phase synthesis of novel quinoxalinones utilizing a UDC (Ugi/de-Boc/cyclize) strategy

Thomas Nixey, Paul Tempest, Christopher Hulme

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

The novel solution-phase synthesis of an array of biologically relevant quinoxalinones in a simple two-step procedure is revealed. Transformations are carried out in excellent yield by condensation of mono-Boc protected ortho-phenylene di-amine, glyoxylic acids and supporting Ugi reagents. Subsequent acid treatment and evaporation affords quinoxalinones in good to excellent yields.

Original languageEnglish (US)
Pages (from-to)1637-1639
Number of pages3
JournalTetrahedron Letters
Volume43
Issue number9
DOIs
StatePublished - Feb 25 2002
Externally publishedYes

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Amines
Condensation
Evaporation
Acids
glyoxylic acid

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Two-step solution-phase synthesis of novel quinoxalinones utilizing a UDC (Ugi/de-Boc/cyclize) strategy. / Nixey, Thomas; Tempest, Paul; Hulme, Christopher.

In: Tetrahedron Letters, Vol. 43, No. 9, 25.02.2002, p. 1637-1639.

Research output: Contribution to journalArticle

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