Two thyroid hormone regulated genes, the β-subunits of nerve growth factor (NGFB) and thyroid stimulating hormone (TSHB), are located less than 310 kb apart in both human and mouse genomes

Nicholas C. Dracopoli, Elise Rose, G. Kerr Whitfield, Peter T. Guidon, Sherri J. Bale, Phillip A. Chance, Ione A. Kourides, David E. Housman

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Two thyroid hormone regulated genes, the β-subunits of nerve growth factor (NGFB) and thyroid stimulating hormone (TSHB), have been assigned to mouse chromosome 3 and human chromosome 1q22. We have used the techniques of linkage analysis and pulsed field gel electrophoresis to determine the proximity of these two antithetically regulated genes in this conserved linkage group. Four novel restriction fragment length polymorphisms were identified at the human TSHB gene. Two-point linkage analysis between TSHB and NGFB in 46 families, including the Centre d'Etude du Polymorphisme Humain (CEPH) reference panel, demonstrated no recombination (θ = 0.00, Z ̂ = 42.8). Analysis of this region by pulsed field gel electrophoresis showed that the genes for TSHB and NGFB are located less than 310 kb apart in man and 220 kb in the mouse.

Original languageEnglish (US)
Pages (from-to)161-167
Number of pages7
JournalGenomics
Volume3
Issue number2
DOIs
StatePublished - Aug 1988

ASJC Scopus subject areas

  • Genetics

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